Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up

Objectives. To investigate the efficacy of infliximab in the treatment of severe calcium pyrophosphate deposition diseases (CPPD). Methods. Two patients with severe CPPD and diffuse idiopathic skeletal hyperostosis- (DISH-) like phenotype are described. Both patients were resistant to therapy with n...

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Autores principales: Bruges-Armas, Jácome, Bettencourt, Bruno F., Couto, Ana R., Lima, Manuela, Rodrigues, Ana M., Vastesaeger, Nathan, Brown, Matthew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243763/
https://www.ncbi.nlm.nih.gov/pubmed/25436167
http://dx.doi.org/10.1155/2014/536856
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author Bruges-Armas, Jácome
Bettencourt, Bruno F.
Couto, Ana R.
Lima, Manuela
Rodrigues, Ana M.
Vastesaeger, Nathan
Brown, Matthew A.
author_facet Bruges-Armas, Jácome
Bettencourt, Bruno F.
Couto, Ana R.
Lima, Manuela
Rodrigues, Ana M.
Vastesaeger, Nathan
Brown, Matthew A.
author_sort Bruges-Armas, Jácome
collection PubMed
description Objectives. To investigate the efficacy of infliximab in the treatment of severe calcium pyrophosphate deposition diseases (CPPD). Methods. Two patients with severe CPPD and diffuse idiopathic skeletal hyperostosis- (DISH-) like phenotype are described. Both patients were resistant to therapy with nonsteroidal anti-inflammatory drugs (NSAIDs). Both patients were treated with infliximab, a TNF-α receptor antagonist, for nine years. Results. Treatment with infliximab resulted in major clinical and laboratory improvements without relevant side effects. Conclusions. These results suggest that infliximab may be an effective treatment of severe CPDD.
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spelling pubmed-42437632014-11-30 Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up Bruges-Armas, Jácome Bettencourt, Bruno F. Couto, Ana R. Lima, Manuela Rodrigues, Ana M. Vastesaeger, Nathan Brown, Matthew A. Case Rep Rheumatol Case Report Objectives. To investigate the efficacy of infliximab in the treatment of severe calcium pyrophosphate deposition diseases (CPPD). Methods. Two patients with severe CPPD and diffuse idiopathic skeletal hyperostosis- (DISH-) like phenotype are described. Both patients were resistant to therapy with nonsteroidal anti-inflammatory drugs (NSAIDs). Both patients were treated with infliximab, a TNF-α receptor antagonist, for nine years. Results. Treatment with infliximab resulted in major clinical and laboratory improvements without relevant side effects. Conclusions. These results suggest that infliximab may be an effective treatment of severe CPDD. Hindawi Publishing Corporation 2014 2014-11-11 /pmc/articles/PMC4243763/ /pubmed/25436167 http://dx.doi.org/10.1155/2014/536856 Text en Copyright © 2014 Jácome Bruges-Armas et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Bruges-Armas, Jácome
Bettencourt, Bruno F.
Couto, Ana R.
Lima, Manuela
Rodrigues, Ana M.
Vastesaeger, Nathan
Brown, Matthew A.
Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up
title Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up
title_full Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up
title_fullStr Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up
title_full_unstemmed Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up
title_short Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up
title_sort effectiveness and safety of infliximab in two cases of severe chondrocalcinosis: nine years of follow-up
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243763/
https://www.ncbi.nlm.nih.gov/pubmed/25436167
http://dx.doi.org/10.1155/2014/536856
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