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Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up
Objectives. To investigate the efficacy of infliximab in the treatment of severe calcium pyrophosphate deposition diseases (CPPD). Methods. Two patients with severe CPPD and diffuse idiopathic skeletal hyperostosis- (DISH-) like phenotype are described. Both patients were resistant to therapy with n...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243763/ https://www.ncbi.nlm.nih.gov/pubmed/25436167 http://dx.doi.org/10.1155/2014/536856 |
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author | Bruges-Armas, Jácome Bettencourt, Bruno F. Couto, Ana R. Lima, Manuela Rodrigues, Ana M. Vastesaeger, Nathan Brown, Matthew A. |
author_facet | Bruges-Armas, Jácome Bettencourt, Bruno F. Couto, Ana R. Lima, Manuela Rodrigues, Ana M. Vastesaeger, Nathan Brown, Matthew A. |
author_sort | Bruges-Armas, Jácome |
collection | PubMed |
description | Objectives. To investigate the efficacy of infliximab in the treatment of severe calcium pyrophosphate deposition diseases (CPPD). Methods. Two patients with severe CPPD and diffuse idiopathic skeletal hyperostosis- (DISH-) like phenotype are described. Both patients were resistant to therapy with nonsteroidal anti-inflammatory drugs (NSAIDs). Both patients were treated with infliximab, a TNF-α receptor antagonist, for nine years. Results. Treatment with infliximab resulted in major clinical and laboratory improvements without relevant side effects. Conclusions. These results suggest that infliximab may be an effective treatment of severe CPDD. |
format | Online Article Text |
id | pubmed-4243763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-42437632014-11-30 Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up Bruges-Armas, Jácome Bettencourt, Bruno F. Couto, Ana R. Lima, Manuela Rodrigues, Ana M. Vastesaeger, Nathan Brown, Matthew A. Case Rep Rheumatol Case Report Objectives. To investigate the efficacy of infliximab in the treatment of severe calcium pyrophosphate deposition diseases (CPPD). Methods. Two patients with severe CPPD and diffuse idiopathic skeletal hyperostosis- (DISH-) like phenotype are described. Both patients were resistant to therapy with nonsteroidal anti-inflammatory drugs (NSAIDs). Both patients were treated with infliximab, a TNF-α receptor antagonist, for nine years. Results. Treatment with infliximab resulted in major clinical and laboratory improvements without relevant side effects. Conclusions. These results suggest that infliximab may be an effective treatment of severe CPDD. Hindawi Publishing Corporation 2014 2014-11-11 /pmc/articles/PMC4243763/ /pubmed/25436167 http://dx.doi.org/10.1155/2014/536856 Text en Copyright © 2014 Jácome Bruges-Armas et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Bruges-Armas, Jácome Bettencourt, Bruno F. Couto, Ana R. Lima, Manuela Rodrigues, Ana M. Vastesaeger, Nathan Brown, Matthew A. Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up |
title | Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up |
title_full | Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up |
title_fullStr | Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up |
title_full_unstemmed | Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up |
title_short | Effectiveness and Safety of Infliximab in Two Cases of Severe Chondrocalcinosis: Nine Years of Follow-Up |
title_sort | effectiveness and safety of infliximab in two cases of severe chondrocalcinosis: nine years of follow-up |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243763/ https://www.ncbi.nlm.nih.gov/pubmed/25436167 http://dx.doi.org/10.1155/2014/536856 |
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