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Contrast Sensitivity Perimetry and Clinical Measures of Glaucomatous Damage
PURPOSE: To compare conventional structural and functional measures of glaucomatous damage with a new functional measure—contrast sensitivity perimetry (CSP-2). METHODS: One eye each was tested for 51 patients with glaucoma and 62 age-similar control subjects using CSP-2, size III 24-2 conventional...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243800/ https://www.ncbi.nlm.nih.gov/pubmed/25259758 http://dx.doi.org/10.1097/OPX.0000000000000395 |
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author | Swanson, William H. Malinovsky, Victor E. Dul, Mitchell W. Malik, Rizwan Torbit, Julie K. Sutton, Bradley M. Horner, Douglas G. |
author_facet | Swanson, William H. Malinovsky, Victor E. Dul, Mitchell W. Malik, Rizwan Torbit, Julie K. Sutton, Bradley M. Horner, Douglas G. |
author_sort | Swanson, William H. |
collection | PubMed |
description | PURPOSE: To compare conventional structural and functional measures of glaucomatous damage with a new functional measure—contrast sensitivity perimetry (CSP-2). METHODS: One eye each was tested for 51 patients with glaucoma and 62 age-similar control subjects using CSP-2, size III 24-2 conventional automated perimetry (CAP), 24-2 frequency-doubling perimetry (FDP), and retinal nerve fiber layer (RNFL) thickness. For superior temporal (ST) and inferior temporal (IT) optic disc sectors, defect depth was computed as amount below mean normal, in log units. Bland-Altman analysis was used to assess agreement on defect depth, using limits of agreement and three indices: intercept, slope, and mean difference. A criterion of p < 0.0014 for significance used Bonferroni correction. RESULTS: Contrast sensitivity perimetry-2 and FDP were in agreement for both sectors. Normal variability was lower for CSP-2 than for CAP and FDP (F > 1.69, p < 0.02), and Bland-Altman limits of agreement for patient data were consistent with variability of control subjects (mean difference, −0.01 log units; SD, 0.11 log units). Intercepts for IT indicated that CSP-2 and FDP were below mean normal when CAP was at mean normal (t > 4, p < 0.0005). Slopes indicated that, as sector damage became more severe, CAP defects for IT and ST deepened more rapidly than CSP-2 defects (t > 4.3, p < 0.0005) and RNFL defects for ST deepened more slowly than for CSP, FDP, and CAP. Mean differences indicated that FDP defects for ST and IT were on average deeper than RNFL defects, as were CSP-2 defects for ST (t > 4.9, p < 0.0001). CONCLUSIONS: Contrast sensitivity perimetry-2 and FDP defects were deeper than CAP defects in optic disc sectors with mild damage and revealed greater residual function in sectors with severe damage. The discordance between different measures of glaucomatous damage can be accounted for by variability in people free of disease. |
format | Online Article Text |
id | pubmed-4243800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-42438002014-11-26 Contrast Sensitivity Perimetry and Clinical Measures of Glaucomatous Damage Swanson, William H. Malinovsky, Victor E. Dul, Mitchell W. Malik, Rizwan Torbit, Julie K. Sutton, Bradley M. Horner, Douglas G. Optom Vis Sci Original Articles PURPOSE: To compare conventional structural and functional measures of glaucomatous damage with a new functional measure—contrast sensitivity perimetry (CSP-2). METHODS: One eye each was tested for 51 patients with glaucoma and 62 age-similar control subjects using CSP-2, size III 24-2 conventional automated perimetry (CAP), 24-2 frequency-doubling perimetry (FDP), and retinal nerve fiber layer (RNFL) thickness. For superior temporal (ST) and inferior temporal (IT) optic disc sectors, defect depth was computed as amount below mean normal, in log units. Bland-Altman analysis was used to assess agreement on defect depth, using limits of agreement and three indices: intercept, slope, and mean difference. A criterion of p < 0.0014 for significance used Bonferroni correction. RESULTS: Contrast sensitivity perimetry-2 and FDP were in agreement for both sectors. Normal variability was lower for CSP-2 than for CAP and FDP (F > 1.69, p < 0.02), and Bland-Altman limits of agreement for patient data were consistent with variability of control subjects (mean difference, −0.01 log units; SD, 0.11 log units). Intercepts for IT indicated that CSP-2 and FDP were below mean normal when CAP was at mean normal (t > 4, p < 0.0005). Slopes indicated that, as sector damage became more severe, CAP defects for IT and ST deepened more rapidly than CSP-2 defects (t > 4.3, p < 0.0005) and RNFL defects for ST deepened more slowly than for CSP, FDP, and CAP. Mean differences indicated that FDP defects for ST and IT were on average deeper than RNFL defects, as were CSP-2 defects for ST (t > 4.9, p < 0.0001). CONCLUSIONS: Contrast sensitivity perimetry-2 and FDP defects were deeper than CAP defects in optic disc sectors with mild damage and revealed greater residual function in sectors with severe damage. The discordance between different measures of glaucomatous damage can be accounted for by variability in people free of disease. Lippincott Williams & Wilkins 2014-11 2014-11-06 /pmc/articles/PMC4243800/ /pubmed/25259758 http://dx.doi.org/10.1097/OPX.0000000000000395 Text en Copyright © 2014 American Academy of Optometry This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. |
spellingShingle | Original Articles Swanson, William H. Malinovsky, Victor E. Dul, Mitchell W. Malik, Rizwan Torbit, Julie K. Sutton, Bradley M. Horner, Douglas G. Contrast Sensitivity Perimetry and Clinical Measures of Glaucomatous Damage |
title | Contrast Sensitivity Perimetry and Clinical Measures of Glaucomatous Damage |
title_full | Contrast Sensitivity Perimetry and Clinical Measures of Glaucomatous Damage |
title_fullStr | Contrast Sensitivity Perimetry and Clinical Measures of Glaucomatous Damage |
title_full_unstemmed | Contrast Sensitivity Perimetry and Clinical Measures of Glaucomatous Damage |
title_short | Contrast Sensitivity Perimetry and Clinical Measures of Glaucomatous Damage |
title_sort | contrast sensitivity perimetry and clinical measures of glaucomatous damage |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243800/ https://www.ncbi.nlm.nih.gov/pubmed/25259758 http://dx.doi.org/10.1097/OPX.0000000000000395 |
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