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Monitoring vigabatrin in head injury patients by cerebral microdialysis: obtaining pharmacokinetic measurements in a neurocritical care setting

AIMS: The aims were to determine blood–brain barrier penetration and brain extracellular pharmacokinetics for the anticonvulsant vigabatrin (VGB; γ-vinyl-γ-aminobutyric acid) in brain extracellular fluid and plasma from severe traumatic brain injury (TBI) patients, and to measure the response of γ-a...

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Detalles Bibliográficos
Autores principales:	Shannon, Richard J, Timofeev, Ivan, Nortje, Jürgens, Hutchinson, Peter J, Carpenter, Keri L H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Pharmacokinetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243872/ https://www.ncbi.nlm.nih.gov/pubmed/24802902 http://dx.doi.org/10.1111/bcp.12414

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