MicroRNA-145: a potent tumour suppressor that regulates multiple cellular pathways

MicroRNAs are endogenous, small (18–25 nucleotides) non-coding RNAs, which regulate genes expression by directly binding to the 3′-untranslated regions of the target messenger RNAs. Emerging evidence shows that alteration of microRNAs is involved in cancer development. MicroRNA-145 is commonly down-...

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Detalles Bibliográficos
Autores principales: Cui, Shi-Yun, Wang, Rui, Chen, Long-Bang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244007/
https://www.ncbi.nlm.nih.gov/pubmed/25124875
http://dx.doi.org/10.1111/jcmm.12358
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author Cui, Shi-Yun
Wang, Rui
Chen, Long-Bang
author_facet Cui, Shi-Yun
Wang, Rui
Chen, Long-Bang
author_sort Cui, Shi-Yun
collection PubMed
description MicroRNAs are endogenous, small (18–25 nucleotides) non-coding RNAs, which regulate genes expression by directly binding to the 3′-untranslated regions of the target messenger RNAs. Emerging evidence shows that alteration of microRNAs is involved in cancer development. MicroRNA-145 is commonly down-regulated in many types of cancer, regulating various cellular processes, such as the cell cycle, proliferation, apoptosis and invasion, by targeting multiple oncogenes. This review aims to summarize the recent published literature on the role of microRNA-145 in regulating tumourigenesis and progression, and explore its potential for cancer diagnosis, prognosis and treatment.
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spelling pubmed-42440072014-12-03 MicroRNA-145: a potent tumour suppressor that regulates multiple cellular pathways Cui, Shi-Yun Wang, Rui Chen, Long-Bang J Cell Mol Med Review MicroRNAs are endogenous, small (18–25 nucleotides) non-coding RNAs, which regulate genes expression by directly binding to the 3′-untranslated regions of the target messenger RNAs. Emerging evidence shows that alteration of microRNAs is involved in cancer development. MicroRNA-145 is commonly down-regulated in many types of cancer, regulating various cellular processes, such as the cell cycle, proliferation, apoptosis and invasion, by targeting multiple oncogenes. This review aims to summarize the recent published literature on the role of microRNA-145 in regulating tumourigenesis and progression, and explore its potential for cancer diagnosis, prognosis and treatment. BlackWell Publishing Ltd 2014-10 2014-08-15 /pmc/articles/PMC4244007/ /pubmed/25124875 http://dx.doi.org/10.1111/jcmm.12358 Text en © 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Cui, Shi-Yun
Wang, Rui
Chen, Long-Bang
MicroRNA-145: a potent tumour suppressor that regulates multiple cellular pathways
title MicroRNA-145: a potent tumour suppressor that regulates multiple cellular pathways
title_full MicroRNA-145: a potent tumour suppressor that regulates multiple cellular pathways
title_fullStr MicroRNA-145: a potent tumour suppressor that regulates multiple cellular pathways
title_full_unstemmed MicroRNA-145: a potent tumour suppressor that regulates multiple cellular pathways
title_short MicroRNA-145: a potent tumour suppressor that regulates multiple cellular pathways
title_sort microrna-145: a potent tumour suppressor that regulates multiple cellular pathways
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244007/
https://www.ncbi.nlm.nih.gov/pubmed/25124875
http://dx.doi.org/10.1111/jcmm.12358
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