Cargando…

Applying a cumulative deficit model of frailty to dementia: progress and future challenges

The article by Song and colleagues presents findings from the Canadian Study of Health and Aging showing that the accumulation of health deficits, defined dichotomously and unqualified by severity or domain, predicted late-life dementia independent of chronological age. We identify strengths of this...

Descripción completa

Detalles Bibliográficos
Autores principales: Anstey, Kaarin J, Dixon, Roger A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244050/
https://www.ncbi.nlm.nih.gov/pubmed/25426173
http://dx.doi.org/10.1186/s13195-014-0084-z
_version_ 1782346176744390656
author Anstey, Kaarin J
Dixon, Roger A
author_facet Anstey, Kaarin J
Dixon, Roger A
author_sort Anstey, Kaarin J
collection PubMed
description The article by Song and colleagues presents findings from the Canadian Study of Health and Aging showing that the accumulation of health deficits, defined dichotomously and unqualified by severity or domain, predicted late-life dementia independent of chronological age. We identify strengths of this model, and also areas for future research. Importantly, this article broadens the perspective of research into measuring risk of dementia from focusing on specific neuropathological markers of dementia subtypes, to mechanisms underlying more general bodily vitality and health, as well as dysfunctions in repair. This work places late-life dementia in a new context, influenced more broadly by health maintenance, and less by specific neurological disease. While useful at a global level, the lack of specificity of this approach may ultimately limit its application to individual patients because without linking risk to etiology, assessment does not indicate an intervention. Ultimately, the article has value for stimulating debate about approaches to risk identification and risk reduction, suggesting that the current focus on cardiometabolic risk factors may be too limited.
format Online
Article
Text
id pubmed-4244050
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-42440502014-11-26 Applying a cumulative deficit model of frailty to dementia: progress and future challenges Anstey, Kaarin J Dixon, Roger A Alzheimers Res Ther Commentary The article by Song and colleagues presents findings from the Canadian Study of Health and Aging showing that the accumulation of health deficits, defined dichotomously and unqualified by severity or domain, predicted late-life dementia independent of chronological age. We identify strengths of this model, and also areas for future research. Importantly, this article broadens the perspective of research into measuring risk of dementia from focusing on specific neuropathological markers of dementia subtypes, to mechanisms underlying more general bodily vitality and health, as well as dysfunctions in repair. This work places late-life dementia in a new context, influenced more broadly by health maintenance, and less by specific neurological disease. While useful at a global level, the lack of specificity of this approach may ultimately limit its application to individual patients because without linking risk to etiology, assessment does not indicate an intervention. Ultimately, the article has value for stimulating debate about approaches to risk identification and risk reduction, suggesting that the current focus on cardiometabolic risk factors may be too limited. BioMed Central 2014-11-26 /pmc/articles/PMC4244050/ /pubmed/25426173 http://dx.doi.org/10.1186/s13195-014-0084-z Text en © Anstey and Dixon; licensee BioMed Central Ltd. 2014 The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Anstey, Kaarin J
Dixon, Roger A
Applying a cumulative deficit model of frailty to dementia: progress and future challenges
title Applying a cumulative deficit model of frailty to dementia: progress and future challenges
title_full Applying a cumulative deficit model of frailty to dementia: progress and future challenges
title_fullStr Applying a cumulative deficit model of frailty to dementia: progress and future challenges
title_full_unstemmed Applying a cumulative deficit model of frailty to dementia: progress and future challenges
title_short Applying a cumulative deficit model of frailty to dementia: progress and future challenges
title_sort applying a cumulative deficit model of frailty to dementia: progress and future challenges
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244050/
https://www.ncbi.nlm.nih.gov/pubmed/25426173
http://dx.doi.org/10.1186/s13195-014-0084-z
work_keys_str_mv AT ansteykaarinj applyingacumulativedeficitmodeloffrailtytodementiaprogressandfuturechallenges
AT dixonrogera applyingacumulativedeficitmodeloffrailtytodementiaprogressandfuturechallenges