Cargando…

High Level of Plasma Matrix Metalloproteinase-11 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma

BACKGROUND: Matrix metalloproteinase-11 (MMP-11) is reported to be overexpressed in several cancers and may contribute to tumorigenesis. The current study investigated the association between the clinicopathological characteristics and plasma level of MMP-11 in oral squamous cell carcinoma (OSCC) pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Hsin, Chung-Han, Chen, Mu-Kuan, Tang, Chih-Hsin, Lin, Huang-Pin, Chou, Ming-Yung, Lin, Chiao-Wen, Yang, Shun-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244114/
https://www.ncbi.nlm.nih.gov/pubmed/25423087
http://dx.doi.org/10.1371/journal.pone.0113129
_version_ 1782346188914163712
author Hsin, Chung-Han
Chen, Mu-Kuan
Tang, Chih-Hsin
Lin, Huang-Pin
Chou, Ming-Yung
Lin, Chiao-Wen
Yang, Shun-Fa
author_facet Hsin, Chung-Han
Chen, Mu-Kuan
Tang, Chih-Hsin
Lin, Huang-Pin
Chou, Ming-Yung
Lin, Chiao-Wen
Yang, Shun-Fa
author_sort Hsin, Chung-Han
collection PubMed
description BACKGROUND: Matrix metalloproteinase-11 (MMP-11) is reported to be overexpressed in several cancers and may contribute to tumorigenesis. The current study investigated the association between the clinicopathological characteristics and plasma level of MMP-11 in oral squamous cell carcinoma (OSCC) patients. METHODOLOGY AND PRINCIPAL FINDINGS: The plasma MMP-11 concentration was determined by ELISA on 330 male OSCC patients. In addition, the metastatic effects of the MMP-11 knockdown on the oral cancer cells were investigated by cell migration assay. Our results showed that the plasma MMP-11 levels were significantly higher in patients with advanced T status (p = 0.001), lymph node metastasis (p = 0.006) and higher TNM stages (p<0.001). Moreover, treatment with the MMP-11 shRNA exerted an inhibitory effect on migration in SCC9 oral cancer cells. CONCLUSION: Our study showed that plasma level of MMP-11 may be useful for assessment of the disease progression, especially lymph node metastasis, in patients with OSCC.
format Online
Article
Text
id pubmed-4244114
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-42441142014-12-05 High Level of Plasma Matrix Metalloproteinase-11 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma Hsin, Chung-Han Chen, Mu-Kuan Tang, Chih-Hsin Lin, Huang-Pin Chou, Ming-Yung Lin, Chiao-Wen Yang, Shun-Fa PLoS One Research Article BACKGROUND: Matrix metalloproteinase-11 (MMP-11) is reported to be overexpressed in several cancers and may contribute to tumorigenesis. The current study investigated the association between the clinicopathological characteristics and plasma level of MMP-11 in oral squamous cell carcinoma (OSCC) patients. METHODOLOGY AND PRINCIPAL FINDINGS: The plasma MMP-11 concentration was determined by ELISA on 330 male OSCC patients. In addition, the metastatic effects of the MMP-11 knockdown on the oral cancer cells were investigated by cell migration assay. Our results showed that the plasma MMP-11 levels were significantly higher in patients with advanced T status (p = 0.001), lymph node metastasis (p = 0.006) and higher TNM stages (p<0.001). Moreover, treatment with the MMP-11 shRNA exerted an inhibitory effect on migration in SCC9 oral cancer cells. CONCLUSION: Our study showed that plasma level of MMP-11 may be useful for assessment of the disease progression, especially lymph node metastasis, in patients with OSCC. Public Library of Science 2014-11-25 /pmc/articles/PMC4244114/ /pubmed/25423087 http://dx.doi.org/10.1371/journal.pone.0113129 Text en © 2014 Hsin et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hsin, Chung-Han
Chen, Mu-Kuan
Tang, Chih-Hsin
Lin, Huang-Pin
Chou, Ming-Yung
Lin, Chiao-Wen
Yang, Shun-Fa
High Level of Plasma Matrix Metalloproteinase-11 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma
title High Level of Plasma Matrix Metalloproteinase-11 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma
title_full High Level of Plasma Matrix Metalloproteinase-11 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma
title_fullStr High Level of Plasma Matrix Metalloproteinase-11 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma
title_full_unstemmed High Level of Plasma Matrix Metalloproteinase-11 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma
title_short High Level of Plasma Matrix Metalloproteinase-11 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma
title_sort high level of plasma matrix metalloproteinase-11 is associated with clinicopathological characteristics in patients with oral squamous cell carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244114/
https://www.ncbi.nlm.nih.gov/pubmed/25423087
http://dx.doi.org/10.1371/journal.pone.0113129
work_keys_str_mv AT hsinchunghan highlevelofplasmamatrixmetalloproteinase11isassociatedwithclinicopathologicalcharacteristicsinpatientswithoralsquamouscellcarcinoma
AT chenmukuan highlevelofplasmamatrixmetalloproteinase11isassociatedwithclinicopathologicalcharacteristicsinpatientswithoralsquamouscellcarcinoma
AT tangchihhsin highlevelofplasmamatrixmetalloproteinase11isassociatedwithclinicopathologicalcharacteristicsinpatientswithoralsquamouscellcarcinoma
AT linhuangpin highlevelofplasmamatrixmetalloproteinase11isassociatedwithclinicopathologicalcharacteristicsinpatientswithoralsquamouscellcarcinoma
AT choumingyung highlevelofplasmamatrixmetalloproteinase11isassociatedwithclinicopathologicalcharacteristicsinpatientswithoralsquamouscellcarcinoma
AT linchiaowen highlevelofplasmamatrixmetalloproteinase11isassociatedwithclinicopathologicalcharacteristicsinpatientswithoralsquamouscellcarcinoma
AT yangshunfa highlevelofplasmamatrixmetalloproteinase11isassociatedwithclinicopathologicalcharacteristicsinpatientswithoralsquamouscellcarcinoma