Nef Neutralizes the Ability of Exosomes from CD4(+) T Cells to Act as Decoys during HIV-1 Infection

Nef is an HIV-1 accessory protein that promotes viral replication and pathogenesis. A key function of Nef is to ensure sustained depletion of CD4 and MHC-I molecules in infected cells by inducing targeting of these proteins to multivesicular bodies (MVBs), and ultimately to lysosomes for degradation...

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Detalles Bibliográficos
Autores principales: de Carvalho, Julianne V., de Castro, Rodrigo O., da Silva, Elaine Z. M., Silveira, Paola P., da Silva-Januário, Mara E., Arruda, Eurico, Jamur, Maria C., Oliver, Constance, Aguiar, Renato S., daSilva, Luis L. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244142/
https://www.ncbi.nlm.nih.gov/pubmed/25423108
http://dx.doi.org/10.1371/journal.pone.0113691

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