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Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation
Parkinson's disease is associated with multiplication of the α-synuclein gene and abnormal accumulation of the protein. In animal models, α-synuclein overexpression broadly impairs synaptic vesicle trafficking. However, the exact steps of the vesicle trafficking pathway affected by excess α-syn...
Autores principales: | Busch, David J., Oliphint, Paul A., Walsh, Rylie B., Banks, Susan M. L., Woods, Wendy S., George, Julia M., Morgan, Jennifer R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244201/ https://www.ncbi.nlm.nih.gov/pubmed/25273557 http://dx.doi.org/10.1091/mbc.E14-02-0708 |
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