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A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks

Functional interpretation of genomic variation is critical to understanding human disease but it remains difficult to predict the effects of specific mutations on protein interaction networks and the phenotypes they regulate. We describe an analytical framework based on multiscale statistical mechan...

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Detalles Bibliográficos
Autores principales: AlQuraishi, Mohammed, Koytiger, Grigoriy, Jenney, Anne, MacBeath, Gavin, Sorger, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244270/
https://www.ncbi.nlm.nih.gov/pubmed/25362484
http://dx.doi.org/10.1038/ng.3138

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