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Brightfield Proximity Ligation Assay Reveals Both Canonical and Mixed Transforming Growth Factor-β/Bone Morphogenetic Protein Smad Signaling Complexes in Tissue Sections

Transforming growth factor-β (TGF-β) is an important regulator of cellular homeostasis and disease pathogenesis. Canonical TGF-β signaling occurs through Smad2/3–Smad4 complexes; however, recent in vitro studies suggest that elevated levels of TGF-β may activate a novel mixed Smad complex (Smad2/3-S...

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Detalles Bibliográficos
Autores principales:	Flanders, Kathleen C., Heger, Christopher D., Conway, Catherine, Tang, Binwu, Sato, Misako, Dengler, Samuel L., Goldsmith, Paul K., Hewitt, Stephen M., Wakefield, Lalage M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244299/ https://www.ncbi.nlm.nih.gov/pubmed/25141865 http://dx.doi.org/10.1369/0022155414550163

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