Integrating computational modeling and functional assays to decipher the structure-function relationship of influenza virus PB1 protein

The influenza virus PB1 protein is the core subunit of the heterotrimeric polymerase complex (PA, PB1 and PB2) in which PB1 is responsible for catalyzing RNA polymerization and binding to the viral RNA promoter. Among the three subunits, PB1 is the least known subunit so far in terms of its structur...

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Detalles Bibliográficos
Autores principales: Li, Chunfeng, Wu, Aiping, Peng, Yousong, Wang, Jingfeng, Guo, Yang, Chen, Zhigao, Zhang, Hong, Wang, Yongqiang, Dong, Jiuhong, Wang, Lulan, Qin, F. Xiao-Feng, Cheng, Genhong, Deng, Tao, Jiang, Taijiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244630/
https://www.ncbi.nlm.nih.gov/pubmed/25424584
http://dx.doi.org/10.1038/srep07192

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