Stability of XIST repression in relation to genomic imprinting following global genome demethylation in a human cell line

DNA methylation is essential in X chromosome inactivation and genomic imprinting, maintaining repression of XIST in the active X chromosome and monoallelic repression of imprinted genes. Disruption of the DNA methyltransferase genes DNMT1 and DNMT3B in the HCT116 cell line (DKO cells) leads to globa...

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Detalles Bibliográficos
Autores principales: de Araújo, E.S.S., Vasques, L.R., Stabellini, R., Krepischi, A.C.V., Pereira, L.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2014
Materias:
Biomedical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244667/
https://www.ncbi.nlm.nih.gov/pubmed/25387668
http://dx.doi.org/10.1590/1414-431X20144058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244667/
https://www.ncbi.nlm.nih.gov/pubmed/25387668
http://dx.doi.org/10.1590/1414-431X20144058

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