Development of Small Molecular Proteasome Inhibitors Using a Caenorhabditis elegans Screen

We have developed a screening protocol to identify compounds with characteristics of small molecule proteasome inhibitors using the real-time analysis of the Caenorhabditis elegans germ line. This screen is able to identify compounds that induce germ line phenotypes characteristic of a reduction in...

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Detalles Bibliográficos
Autores principales: Nayak, Sudhir, Fiaschi, Michela, King, Dana, Tabakin, Erica R., Wood, Lyndsay, Hunt, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244688/
https://www.ncbi.nlm.nih.gov/pubmed/25436151
http://dx.doi.org/10.1155/2014/237286

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