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Synthesis of α-Amino Acid Derivatives and Peptides via Enantioselective Addition of Masked Acyl Cyanides to Imines

[Image: see text] A general, asymmetric synthesis of amino acid derivatives is reported. Masked acyl cyanide (MAC) reagents are shown to be effective umpolung synthons for enantioselective additions to N-Boc-aldimines. The reactions are catalyzed by a modified cinchona alkaloid, which can function a...

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Detalles Bibliográficos
Autores principales:	Yang, Kin S., Rawal, Viresh H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244832/ https://www.ncbi.nlm.nih.gov/pubmed/25366558 http://dx.doi.org/10.1021/ja510135t

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