Catalytic Z-Selective Cross-Metathesis in Complex Molecule Synthesis: A Convergent Stereoselective Route to Disorazole C(1)

[Image: see text] A convergent diastereo- and enantioselective total synthesis of anticancer and antifungal macrocyclic natural product disorazole C(1) is reported. The central feature of the successful route is the application of catalytic Z-selective cross-metathesis (CM). Specifically, we illustr...

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Detalles Bibliográficos
Autores principales: Speed, Alexander W. H., Mann, Tyler J., O’Brien, Robert V., Schrock, Richard R., Hoveyda, Amir H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244837/
https://www.ncbi.nlm.nih.gov/pubmed/25379808
http://dx.doi.org/10.1021/ja509973r

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