Cargando…

Incubation of MDCO-216 (ApoA-IMilano/POPC) with Human Serum Potentiates ABCA1-Mediated Cholesterol Efflux Capacity, Generates New Prebeta-1 HDL, and Causes an Increase in HDL Size

MDCO-216 is a complex of dimeric ApoA-IMilano and palmitoyl oleoyl phosphatidylcholine (POPC), previously shown to reduce atherosclerotic plaque burden. Here we studied the effect of incubation of human plasma or serum with MDCO-216 on cholesterol efflux capacity from J774 cells, on prebeta-1 high d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kempen, Herman J., Schranz, Dorota B., Asztalos, Bela F., Otvos, James, Jeyarajah, Elias, Drazul-Schrader, Denise, Collins, Heidi L., Adelman, Steven J., Wijngaard, Peter L. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244927/ https://www.ncbi.nlm.nih.gov/pubmed/25478232 http://dx.doi.org/10.1155/2014/923903

Ejemplares similares

A single infusion of MDCO-216 (ApoA-1 Milano/POPC) increases ABCA1-mediated cholesterol efflux and pre-beta 1 HDL in healthy volunteers and patients with stable coronary artery disease
por: Kallend, D.G., et al.
Publicado: (2016)

MDCO-216 Does Not Induce Adverse Immunostimulation, in Contrast to Its Predecessor ETC-216
por: Reijers, Joannes A. A., et al.
Publicado: (2017)

Will Lipidation of ApoA1 through Interaction with ABCA1 at the Intestinal Level Affect the Protective Functions of HDL?
por: Niesor, Eric J.
Publicado: (2015)

The Effects of Rope Training on Lymphocyte ABCA1 Expression, Plasma ApoA-I and HDL-c in Boy Adolescents
por: Ghorbanian, Bahloul, et al.
Publicado: (2013)

Current and Emerging Reconstituted HDL-apoA-I and HDL-apoE Approaches to Treat Atherosclerosis
por: Valanti, Eftaxia-Konstantina, et al.
Publicado: (2018)

HDL/ApoA-1 infusion and ApoA-1 gene therapy in atherosclerosis
por: Chyu, Kuang-Yuh, et al.
Publicado: (2015)

HDL-apoA-I Exchange: Rapid Detection and Association with Atherosclerosis
por: Borja, Mark S., et al.
Publicado: (2013)

Hepatocyte ABCA1 deficiency is associated with reduced HDL sphingolipids
por: Othman, Alaa, et al.
Publicado: (2023)

Effect of weight loss on HDL-apoA-II kinetics in the metabolic syndrome
por: Ng, Theodore W. K., et al.
Publicado: (2009)

The effects of serum TC, HDL, APOA-I levels on the prognosis of sepsis patients
por: Zhang, T, et al.
Publicado: (2015)

Association between the APOA2 rs3813627 Single Nucleotide Polymorphism and HDL and APOA1 Levels Through BMI
por: Boughanem, Hatim, et al.
Publicado: (2020)

Neuroprotective efficacy of ABCA1 and HDL in aging rats with cerebrovascular hypoperfusion
por: Wang, Linhui, et al.
Publicado: (2012)

Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway
por: Pamir, Nathalie, et al.
Publicado: (2016)

Discoidal HDL and apoA-I-derived peptides improve glucose uptake in skeletal muscle
por: Dalla-Riva, Jonathan, et al.
Publicado: (2013)

In Vivo Inflammation Does Not Impair ABCA1-Mediated Cholesterol Efflux Capacity of HDL
por: Franssen, Remco, et al.
Publicado: (2012)

An apoA-I mimetic peptide increases LCAT activity in mice through increasing HDL concentration
por: Chen, Xun, et al.
Publicado: (2009)

Protective and therapeutic potentials of HDL and ApoA1 in COVID-19 elderly and chronic illness patients
por: AbdelHafez, Mohamed Aly
Publicado: (2022)

HDL-apoA-II Is Strongly Associated with 1-Year Mortality in Acute Heart Failure Patients
por: Klobučar, Iva, et al.
Publicado: (2022)

Human Serum Amyloid a Impaired Structural Stability of High-Density Lipoproteins (HDL) and Apolipoprotein (Apo) A-I and Exacerbated Glycation Susceptibility of ApoA-I and HDL
por: Cho, Kyung-Hyun
Publicado: (2022)

APOA1-75 G to A Substitution Associated with Severe Forms of CAD, Lower Levels of HDL and apoA-I among Northern Indians
por: Chhabra, S., et al.
Publicado: (2005)

Single nucleotide polymorphisms in CETP, SLC46A1, SLC19A1, CD36, BCMO1, APOA5, and ABCA1 are significant predictors of plasma HDL in healthy adults
por: Clifford, Andrew J, et al.
Publicado: (2013)

The Current Status of Research on High-Density Lipoproteins (HDL): A Paradigm Shift from HDL Quantity to HDL Quality and HDL Functionality
por: Cho, Kyung-Hyun
Publicado: (2022)

Different Functional and Structural Characteristics between ApoA-I and ApoA-4 in Lipid-Free and Reconstituted HDL State: ApoA-4 Showed Less Anti-Atherogenic Activity
por: Yoo, Jeong-Ah, et al.
Publicado: (2015)

Adrenal Function in Females with Low Plasma HDL-C Due to Mutations in ABCA1 and LCAT
por: Bochem, Andrea E., et al.
Publicado: (2014)

Hepatic ACAT2 Knock Down Increases ABCA1 and Modifies HDL Metabolism in Mice
por: Pedrelli, Matteo, et al.
Publicado: (2014)

Exposure to High Glucose Concentration Decreases Cell Surface ABCA1 and HDL Biogenesis in Hepatocytes
por: Tsujita, Maki, et al.
Publicado: (2017)

Allele-specific enhancers mediate associations between LCAT and ABCA1 polymorphisms and HDL metabolism
por: Howard, Alicia D., et al.
Publicado: (2019)

ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke
por: Li, Li, et al.
Publicado: (2020)

Alterations of HDL’s to piHDL’s Proteome in Patients with Chronic Inflammatory Diseases, and HDL-Targeted Therapies
por: Vyletelová, Veronika, et al.
Publicado: (2022)

HDL Cholesterol Story Is Dead: Long Live HDL!
por: Simha, Vinaya, et al.
Publicado: (2016)

ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer
por: Cedó, Lídia, et al.
Publicado: (2016)

Comparison of apoA-I helical structure and stability in discoidal and spherical HDL particles by HX and mass spectrometry
por: Chetty, Palaniappan Sevugan, et al.
Publicado: (2013)

Triglyceride-raising APOA5 genetic variants are associated with obesity and non-HDL-C in Chinese children and adolescents
por: Zhu, Wei-fen, et al.
Publicado: (2014)

ApoA-I/HDL Generation and Intracellular Cholesterol Transport through Cytosolic Lipid-Protein Particles in Astrocytes
por: Ito, Jinichi, et al.
Publicado: (2014)

Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux
por: Daniil, Georgios, et al.
Publicado: (2013)

Synchrotron radiation circular dichroism spectroscopy reveals structural divergences in HDL-bound apoA-I variants
por: Giudice, Rita Del, et al.
Publicado: (2017)

The effect of weight loss on HDL subfractions and LCAT activity in two genotypes of APOA-II -265T>C polymorphism
por: Moradi, Masoumeh, et al.
Publicado: (2017)

Structure dynamics of ApoA-I amyloidogenic variants in small HDL increase their ability to mediate cholesterol efflux
por: Nilsson, Oktawia, et al.
Publicado: (2020)

The ratio of HDL-C to apoA-I interacts with free triiodothyronine to modulate coronary artery disease risk
por: Li, Li, et al.
Publicado: (2021)

Human apoA-I[Lys107del] mutation affects lipid surface behavior of apoA-I and its ability to form large nascent HDL
por: Gorshkova, Irina N., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gfkpe6njsng54he1uktjrg7g6o