Monoclonal Antibody Targeting of Fibroblast Growth Factor Receptor 1c Ameliorates Obesity and Glucose Intolerance via Central Mechanisms

We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in turn improving glucose control. R1c mAb also caused weight loss in leptin-...

Descripción completa

Detalles Bibliográficos
Autores principales: Lelliott, Christopher J., Ahnmark, Andrea, Admyre, Therese, Ahlstedt, Ingela, Irving, Lorraine, Keyes, Feenagh, Patterson, Laurel, Mumphrey, Michael B., Bjursell, Mikael, Gorman, Tracy, Bohlooly-Y, Mohammad, Buchanan, Andrew, Harrison, Paula, Vaughan, Tristan, Berthoud, Hans-Rudolf, Lindén, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245083/
https://www.ncbi.nlm.nih.gov/pubmed/25427253
http://dx.doi.org/10.1371/journal.pone.0112109

Ejemplares similares

Ejemplares similares