Cargando…

Identification of Small Molecule Modulators of Gene Transcription with Anticancer Activity

[Image: see text] Epigenetic regulation of gene expression is essential in many biological processes, and its deregulation contributes to pathology including tumor formation. We used an image-based cell assay that measures the induction of a silenced GFP-estrogen receptor reporter to identify novel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tran, Tram Anh, Wichterman-Kouznetsova, Jennifer, Varghese, Diana, Huang, Ruili, Huang, Wenwei, Becker, Matthias, Austin, Christopher P., Inglese, James, Johnson, Ronald L., Martinez, Elisabeth D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245161/ https://www.ncbi.nlm.nih.gov/pubmed/25188650 http://dx.doi.org/10.1021/cb500532x

Ejemplares similares

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum
por: Yuan, Jing, et al.
Publicado: (2009)

Identification of small molecule compounds that inhibit the HIF-1 signaling pathway
por: Xia, Menghang, et al.
Publicado: (2009)

Editorial: Small organic molecules with anticancer activity
por: Rahman, A. F. M. Motiur, et al.
Publicado: (2023)

Identification of repurposed small molecule drugs for chordoma therapy
por: Xia, Menghang, et al.
Publicado: (2013)

Small Molecule Decoys of Aggregation for Elimination of Aβ-Peptide Toxicity
por: Oasa, Sho, et al.
Publicado: (2023)

A Cell-Based β-Lactamase Reporter Gene Assay for the CREB Signaling Pathway
por: Xia, Menghang, et al.
Publicado: (2009)

Small molecules targeting Pin1 as potent anticancer drugs
por: Zhang, Jing, et al.
Publicado: (2023)

A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma
por: Yenugonda, Venkata, et al.
Publicado: (2017)

In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia
por: Clavel, Catherine M., et al.
Publicado: (2015)

Synthesis and Biological Evaluation of Small Molecules as Potential Anticancer Multitarget Agents
por: Pla-López, Alberto, et al.
Publicado: (2022)

Imidazolylpyrrolone‐Based Small Molecules as Anticancer Agents for Renal Cell Carcinoma
por: Sousa, Ana, et al.
Publicado: (2022)

Benzoquinoline Derivatives: An Attractive Approach to Newly Small Molecules with Anticancer Activity
por: Oniciuc, Liliana, et al.
Publicado: (2023)

The multi-target small-molecule inhibitor SB747651A shows in vitro and in vivo anticancer efficacy in glioblastomas
por: Knudsen, Arnon Møldrup, et al.
Publicado: (2021)

Anticancer activity of a novel small molecule tubulin inhibitor STK899704
por: Sakchaisri, Krisada, et al.
Publicado: (2017)

Salinomycin-Loaded Small-Molecule Nanoprodrugs Enhance Anticancer Activity in Hepatocellular Carcinoma
por: Wang, Jianguo, et al.
Publicado: (2020)

Small-Molecule RAS Inhibitors as Anticancer Agents: Discovery, Development, and Mechanistic Studies
por: Shetu, Shaila A., et al.
Publicado: (2022)

A New Bioassay Platform Design for the Discovery of Small Molecules with Anticancer Immunotherapeutic Activity
por: Gallo, Carmela, et al.
Publicado: (2020)

Cellular delivery of dinucleotides by conjugation with small molecules: targeting translation initiation for anticancer applications
por: Kleczewska, Natalia, et al.
Publicado: (2021)

A High Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of gsp
por: Bhattacharyya, Nisan, et al.
Publicado: (2014)

Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection
por: Shamim, Khalida, et al.
Publicado: (2021)

Small-molecule targeting of brachyury transcription factor addiction in chordoma
por: Sharifnia, Tanaz, et al.
Publicado: (2019)

Natural Anticancer Molecules and Their Therapeutic Potential
por: Zhang, Junmin, et al.
Publicado: (2023)

Small molecule allosteric modulation of the adenosine A(1) receptor
por: Nguyen, Anh T. N., et al.
Publicado: (2023)

Reprogramming with Small Molecules instead of Exogenous Transcription Factors
por: Lin, Tongxiang, et al.
Publicado: (2015)

Dual Small-Molecule Targeting of Procaspase-3 Dramatically Enhances Zymogen Activation and Anticancer Activity
por: Botham, Rachel C., et al.
Publicado: (2014)

The Design and Development of Potent Small Molecules as Anticancer Agents Targeting EGFR TK and Tubulin Polymerization
por: Ihmaid, Saleh, et al.
Publicado: (2018)

Small Molecule Inhibitors of HSF1-Activated Pathways as Potential Next-Generation Anticancer Therapeutics
por: Sharma, Chiranjeev, et al.
Publicado: (2018)

Recent development of ATP-competitive small molecule phosphatidylinostitol-3-kinase inhibitors as anticancer agents
por: Liu, Yu, et al.
Publicado: (2016)

Research Progress of Small Molecule VEGFR/c-Met Inhibitors as Anticancer Agents (2016–Present)
por: Zhang, Qian, et al.
Publicado: (2020)

Insight into norcantharidin, a small-molecule synthetic compound with potential multi-target anticancer activities
por: Pan, Mu-Su, et al.
Publicado: (2020)

Recent Developments in Small-Molecule Ligands of Medicinal Relevance for Harnessing the Anticancer Potential of G-Quadruplexes
por: Savva, Loukiani, et al.
Publicado: (2021)

Screening of the small molecule library of Meinox enables the identification of anticancer compounds in pathologically distinct cancers
por: MAMMADOVA, Aynura, et al.
Publicado: (2021)

pdCSM-cancer: Using Graph-Based Signatures to Identify Small Molecules with Anticancer Properties
por: Al-Jarf, Raghad, et al.
Publicado: (2021)

Synthetic Small Molecule Modulators of Hsp70 and Hsp40 Chaperones as Promising Anticancer Agents
por: Nitzsche, Bianca, et al.
Publicado: (2023)

Structure-based discovery of a novel small-molecule inhibitor of TEAD palmitoylation with anticancer activity
por: Gridnev, Artem, et al.
Publicado: (2022)

Anticancer Small-Molecule Agents Targeting Eukaryotic Elongation Factor 1A: State of the Art
por: Zhang, Han, et al.
Publicado: (2023)

Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma
por: Tsigelny, Igor F., et al.
Publicado: (2015)

Oxoisoaporphines and Aporphines: Versatile Molecules with Anticancer Effects
por: Rodríguez-Arce, Esteban, et al.
Publicado: (2019)

Identification of Small Molecule Activators of BMP Signaling
por: Vrijens, Karen, et al.
Publicado: (2013)

Soil-Transmitted Helminth Infection and Its Association with Anemia and Zinc Deficiency among Women in Nghe An Province, Vietnam
por: THI TRAN, Kieu-Anh, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_97f1c68ahim9ednuoad49ifcrb