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Tethering Membrane Fusion: Common and Different Players in Myoblasts and at the Synapse

DROSOPHILA: Membrane fusion is essential for the communication of membrane-defined compartments, development of multicellular organisms and tissue homeostasis. Although membrane fusion has been studied extensively, still little is known about the molecular mechanisms. Especially the intercellular fu...

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Autores principales: Önel, Susanne Filiz, Rust, Marco B., Jacob, Ralf, Renkawitz-Pohl, Renate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245166/
https://www.ncbi.nlm.nih.gov/pubmed/24957080
http://dx.doi.org/10.3109/01677063.2014.936014
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author Önel, Susanne Filiz
Rust, Marco B.
Jacob, Ralf
Renkawitz-Pohl, Renate
author_facet Önel, Susanne Filiz
Rust, Marco B.
Jacob, Ralf
Renkawitz-Pohl, Renate
author_sort Önel, Susanne Filiz
collection PubMed
description DROSOPHILA: Membrane fusion is essential for the communication of membrane-defined compartments, development of multicellular organisms and tissue homeostasis. Although membrane fusion has been studied extensively, still little is known about the molecular mechanisms. Especially the intercellular fusion of cells during development and tissue homeostasis is poorly understood. Somatic muscle formation in Drosophila depends on the intercellular fusion of myoblasts. In this process, myoblasts recognize each other and adhere, thereby triggering a protein machinery that leads to electron-dense plaques, vesicles and F-actin formation at apposing membranes. Two models of how local membrane stress is achieved to induce the merging of the myoblast membranes have been proposed: the electron-dense vesicles transport and release a fusogen and F-actin bends the plasma membrane. In this review, we highlight cell-adhesion molecules and intracellular proteins known to be involved in myoblast fusion. The cell-adhesion proteins also mediate the recognition and adhesion of other cell types, such as neurons that communicate with each other via special intercellular junctions, termed chemical synapses. At these synapses, neurotransmitters are released through the intracellular fusion of synaptic vesicles with the plasma membrane. As the targeting of electron-dense vesicles in myoblasts shares some similarities with the targeting of synaptic vesicle fusion, we compare molecules required for synaptic vesicle fusion to recently identified molecules involved in myoblast fusion.
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spelling pubmed-42451662014-12-08 Tethering Membrane Fusion: Common and Different Players in Myoblasts and at the Synapse Önel, Susanne Filiz Rust, Marco B. Jacob, Ralf Renkawitz-Pohl, Renate J Neurogenet Review DROSOPHILA: Membrane fusion is essential for the communication of membrane-defined compartments, development of multicellular organisms and tissue homeostasis. Although membrane fusion has been studied extensively, still little is known about the molecular mechanisms. Especially the intercellular fusion of cells during development and tissue homeostasis is poorly understood. Somatic muscle formation in Drosophila depends on the intercellular fusion of myoblasts. In this process, myoblasts recognize each other and adhere, thereby triggering a protein machinery that leads to electron-dense plaques, vesicles and F-actin formation at apposing membranes. Two models of how local membrane stress is achieved to induce the merging of the myoblast membranes have been proposed: the electron-dense vesicles transport and release a fusogen and F-actin bends the plasma membrane. In this review, we highlight cell-adhesion molecules and intracellular proteins known to be involved in myoblast fusion. The cell-adhesion proteins also mediate the recognition and adhesion of other cell types, such as neurons that communicate with each other via special intercellular junctions, termed chemical synapses. At these synapses, neurotransmitters are released through the intracellular fusion of synaptic vesicles with the plasma membrane. As the targeting of electron-dense vesicles in myoblasts shares some similarities with the targeting of synaptic vesicle fusion, we compare molecules required for synaptic vesicle fusion to recently identified molecules involved in myoblast fusion. Informa Healthcare 2014-12 2014-07-24 /pmc/articles/PMC4245166/ /pubmed/24957080 http://dx.doi.org/10.3109/01677063.2014.936014 Text en © 2014 Informa Healthcare USA, Inc. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the CC-BY-NC-ND 3.0 License which permits users to download and share the article for non-commercial purposes, so long as the article is reproduced in the whole without changes, and provided the original source is credited.
spellingShingle Review
Önel, Susanne Filiz
Rust, Marco B.
Jacob, Ralf
Renkawitz-Pohl, Renate
Tethering Membrane Fusion: Common and Different Players in Myoblasts and at the Synapse
title Tethering Membrane Fusion: Common and Different Players in Myoblasts and at the Synapse
title_full Tethering Membrane Fusion: Common and Different Players in Myoblasts and at the Synapse
title_fullStr Tethering Membrane Fusion: Common and Different Players in Myoblasts and at the Synapse
title_full_unstemmed Tethering Membrane Fusion: Common and Different Players in Myoblasts and at the Synapse
title_short Tethering Membrane Fusion: Common and Different Players in Myoblasts and at the Synapse
title_sort tethering membrane fusion: common and different players in myoblasts and at the synapse
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245166/
https://www.ncbi.nlm.nih.gov/pubmed/24957080
http://dx.doi.org/10.3109/01677063.2014.936014
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