Cargando…

Structure–Activity Relationships of a Novel Capsid Targeted Inhibitor of HIV-1 Replication

[Image: see text] Despite the considerable successes of highly active antiretroviral therapy (HAART) for the treatment of HIV/AIDS, cumulative drug toxicities and the development of multidrug-resistant virus necessitate the search for new classes of antiretroviral agents with novel modes of action....

Descripción completa

Detalles Bibliográficos
Autores principales:	Kortagere, Sandhya, Xu, Jimmy P., Mankowski, Marie K., Ptak, Roger G., Cocklin, Simon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245176/ https://www.ncbi.nlm.nih.gov/pubmed/25302989 http://dx.doi.org/10.1021/ci500437r

Ejemplares similares

Structure, Function, and Interactions of the HIV-1 Capsid Protein
por: Rossi, Eric, et al.
Publicado: (2021)

Structure–Activity Relationship Studies of Indole-Based Compounds as Small Molecule HIV-1 Fusion Inhibitors Targeting Glycoprotein 41
por: Zhou, Guangyan, et al.
Publicado: (2014)

Clade-Specific Alterations within the HIV-1 Capsid Protein with Implications for Nuclear Translocation
por: Dick, Alexej, et al.
Publicado: (2022)

Design, Synthesis and Structure—Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction
por: Ji, Xiangkai, et al.
Publicado: (2022)

Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors
por: Jiang, Xiangyi, et al.
Publicado: (2019)

Gyrase B Inhibitor Impairs HIV-1 Replication by Targeting Hsp90 and the Capsid Protein
por: Vozzolo, Luciano, et al.
Publicado: (2010)

Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency
por: Meuser, Megan E., et al.
Publicado: (2018)

Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators
por: Zhang, Xujie, et al.
Publicado: (2022)

Recent Advances in HIV-1 Gag Inhibitor Design and Development
por: Dick, Alexej, et al.
Publicado: (2020)

Composition and Orientation of the Core Region of Novel HIV-1 Entry Inhibitors Influences Metabolic Stability
por: Karadsheh, Rama, et al.
Publicado: (2020)

HIV Capsid and Integration Targeting
por: Engelman, Alan N.
Publicado: (2021)

HIV-1 capsid is the key orchestrator of early viral replication
por: Zila, Vojtech, et al.
Publicado: (2021)

Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules
por: Vernekar, Sanjeev Kumar V., et al.
Publicado: (2020)

Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators
por: Xu, Shujing, et al.
Publicado: (2022)

Correlation of Naturally Occurring HIV-1 Resistance to DEB025 with Capsid Amino Acid Polymorphisms
por: Gallay, Philippe A., et al.
Publicado: (2013)

Novel capsid binder and PI4KIIIbeta inhibitors for EV-A71 replication inhibition
por: Tan, Yong Wah, et al.
Publicado: (2021)

Capsid-Targeted Viral Inactivation: A Novel Tactic for Inhibiting Replication in Viral Infections
por: Zhang, Xingcui, et al.
Publicado: (2016)

HIV Capsid Inhibitors Beyond PF74
por: McArthur, Carole, et al.
Publicado: (2019)

Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle
por: Novikova, Mariia, et al.
Publicado: (2019)

Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir
por: Bester, Stephanie M., et al.
Publicado: (2022)

HIV Capsid Protein Genetic Diversity Across HIV-1 Variants and Impact on New Capsid-Inhibitor Lenacapavir
por: Troyano-Hernáez, Paloma, et al.
Publicado: (2022)

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency
por: Schaller, Torsten, et al.
Publicado: (2011)

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor
por: Meuser, Megan E., et al.
Publicado: (2019)

Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding
por: Stacey, James C. V., et al.
Publicado: (2023)

Antiviral Properties of HIV-1 Capsid Inhibitor GSK878
por: Wang, Chunfu, et al.
Publicado: (2023)

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication
por: Price, Amanda J., et al.
Publicado: (2012)

Targeting the HIV-1 and HBV Capsids, an EnCore
por: McFadden, William M., et al.
Publicado: (2023)

Pyrazolopyrimidines: Potent Inhibitors Targeting the Capsid of Rhino- and Enteroviruses
por: Makarov, Vadim A, et al.
Publicado: (2015)

Overview of the structure and function of the dopamine transporter and its protein interactions
por: Nepal, Binod, et al.
Publicado: (2023)

Structure-based virtual screening workflow to identify antivirals targeting HIV-1 capsid
por: Sun, Qinfang, et al.
Publicado: (2022)

Gag-protease coevolution analyses define novel structural surfaces in the HIV-1 matrix and capsid involved in resistance to Protease Inhibitors
por: Codoñer, Francisco M, et al.
Publicado: (2017)

Bioisosteric Replacement as a Tool in Anti-HIV Drug Design
por: Dick, Alexej, et al.
Publicado: (2020)

Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid
por: Peng, Ke, et al.
Publicado: (2014)

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention
por: Blair, Wade S., et al.
Publicado: (2010)

Subtype Differences in the Interaction of HIV-1 Matrix with Calmodulin: Implications for Biological Functions
por: Dick, Alexej, et al.
Publicado: (2021)

Rotten to the core: antivirals targeting the HIV-1 capsid core
por: McFadden, William M., et al.
Publicado: (2021)

New RAD51 Inhibitors to Target Homologous Recombination in Human Cells
por: Shkundina, Irina S., et al.
Publicado: (2021)

Structure-Based Discovery of N-Sulfonylpiperidine-3-Carboxamides as Novel Capsid Assembly Modulators for Potent Inhibition of HBV Replication
por: Yang, Yang, et al.
Publicado: (2022)

Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design
por: Shechter, Sharon, et al.
Publicado: (2017)

Designing modulators of monoamine transporters using virtual screening techniques
por: Mortensen, Ole V., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_kc4sua5smm5q7fliavpdnjfle1