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Associations between Disease Awareness and Health-Related Quality of Life in a Multi-Ethnic Asian Population
BACKGROUND: Health related quality of life (HRQoL) is an important dimension of individuals' well-being, and especially in chronic diseases like diabetes and hypertension. The objective of this study was to evaluate the contributions of disease process, comorbidities, medication or awareness of...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245227/ https://www.ncbi.nlm.nih.gov/pubmed/25426951 http://dx.doi.org/10.1371/journal.pone.0113802 |
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author | Venkataraman, Kavita Khoo, ChinMeng Wee, Hwee Lin Tan, Chuen Seng Ma, Stefan Heng, Derrick Lee, Jeannette Tai, E. Shyong Thumboo, Julian |
author_facet | Venkataraman, Kavita Khoo, ChinMeng Wee, Hwee Lin Tan, Chuen Seng Ma, Stefan Heng, Derrick Lee, Jeannette Tai, E. Shyong Thumboo, Julian |
author_sort | Venkataraman, Kavita |
collection | PubMed |
description | BACKGROUND: Health related quality of life (HRQoL) is an important dimension of individuals' well-being, and especially in chronic diseases like diabetes and hypertension. The objective of this study was to evaluate the contributions of disease process, comorbidities, medication or awareness of the disease to HRQoL in diabetes mellitus, hypertension and dyslipidemia. METHODS: This was a cross-sectional study of 3514 respondents from the general community in Singapore, assessed for HRQoL, disease and comorbid conditions through self-report, clinical and laboratory investigations. HRQoL was assessed using SF-36 health survey version 2. For each condition, participants were categorized as having 1) no disease, 2) undiagnosed, 3) diagnosed, not taking medication, and 4) diagnosed, taking medication. Analysis used one-way ANOVA and multiple linear regression. RESULTS: Diagnosed disease was associated with lower physical health component summary (PCS) scores across all three conditions. After adjustment for comorbidities, this association remained significant only for those not on medication in diabetes (−2.7±1.2 points, p = 0.03) and dyslipidemia (−1.3±0.4 points, p = 0.003). Diagnosed hypertension (no medication −2.6±0.9 points, p = 0.002; medication −1.4±0.5 points, p = 0.004) and dyslipidemia (no medication −0.9±0.4 points, p = 0.03; medication −1.9±0.5 points, p<0.001) were associated with lower mental health component summary (MCS) scores. Undiagnosed disease was associated with higher MCS in diabetes (2.4±1.0 points, p = 0.01) and dyslipidemia (0.8±0.4 points, p = 0.045), and PCS in hypertension (1.2±0.4 points, p = 0.004). CONCLUSIONS: Disease awareness was associated with lower HRQoL across the diseases studied, with PCS associations partially mediated by comorbidities. Equally importantly, undiagnosed disease was not associated with HRQoL deficits, which may partly explain why these individuals do not seek medical care. |
format | Online Article Text |
id | pubmed-4245227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-42452272014-12-05 Associations between Disease Awareness and Health-Related Quality of Life in a Multi-Ethnic Asian Population Venkataraman, Kavita Khoo, ChinMeng Wee, Hwee Lin Tan, Chuen Seng Ma, Stefan Heng, Derrick Lee, Jeannette Tai, E. Shyong Thumboo, Julian PLoS One Research Article BACKGROUND: Health related quality of life (HRQoL) is an important dimension of individuals' well-being, and especially in chronic diseases like diabetes and hypertension. The objective of this study was to evaluate the contributions of disease process, comorbidities, medication or awareness of the disease to HRQoL in diabetes mellitus, hypertension and dyslipidemia. METHODS: This was a cross-sectional study of 3514 respondents from the general community in Singapore, assessed for HRQoL, disease and comorbid conditions through self-report, clinical and laboratory investigations. HRQoL was assessed using SF-36 health survey version 2. For each condition, participants were categorized as having 1) no disease, 2) undiagnosed, 3) diagnosed, not taking medication, and 4) diagnosed, taking medication. Analysis used one-way ANOVA and multiple linear regression. RESULTS: Diagnosed disease was associated with lower physical health component summary (PCS) scores across all three conditions. After adjustment for comorbidities, this association remained significant only for those not on medication in diabetes (−2.7±1.2 points, p = 0.03) and dyslipidemia (−1.3±0.4 points, p = 0.003). Diagnosed hypertension (no medication −2.6±0.9 points, p = 0.002; medication −1.4±0.5 points, p = 0.004) and dyslipidemia (no medication −0.9±0.4 points, p = 0.03; medication −1.9±0.5 points, p<0.001) were associated with lower mental health component summary (MCS) scores. Undiagnosed disease was associated with higher MCS in diabetes (2.4±1.0 points, p = 0.01) and dyslipidemia (0.8±0.4 points, p = 0.045), and PCS in hypertension (1.2±0.4 points, p = 0.004). CONCLUSIONS: Disease awareness was associated with lower HRQoL across the diseases studied, with PCS associations partially mediated by comorbidities. Equally importantly, undiagnosed disease was not associated with HRQoL deficits, which may partly explain why these individuals do not seek medical care. Public Library of Science 2014-11-26 /pmc/articles/PMC4245227/ /pubmed/25426951 http://dx.doi.org/10.1371/journal.pone.0113802 Text en © 2014 Venkataraman et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Venkataraman, Kavita Khoo, ChinMeng Wee, Hwee Lin Tan, Chuen Seng Ma, Stefan Heng, Derrick Lee, Jeannette Tai, E. Shyong Thumboo, Julian Associations between Disease Awareness and Health-Related Quality of Life in a Multi-Ethnic Asian Population |
title | Associations between Disease Awareness and Health-Related Quality of Life in a Multi-Ethnic Asian Population |
title_full | Associations between Disease Awareness and Health-Related Quality of Life in a Multi-Ethnic Asian Population |
title_fullStr | Associations between Disease Awareness and Health-Related Quality of Life in a Multi-Ethnic Asian Population |
title_full_unstemmed | Associations between Disease Awareness and Health-Related Quality of Life in a Multi-Ethnic Asian Population |
title_short | Associations between Disease Awareness and Health-Related Quality of Life in a Multi-Ethnic Asian Population |
title_sort | associations between disease awareness and health-related quality of life in a multi-ethnic asian population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245227/ https://www.ncbi.nlm.nih.gov/pubmed/25426951 http://dx.doi.org/10.1371/journal.pone.0113802 |
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