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Human papillomavirus 18 as a poor prognostic factor in stage I-IIA cervical cancer following primary surgical treatment

OBJECTIVE: This study evaluates the effect of the specific human papillomavirus (HPV) genotype as a prognostic factor in stage I-IIA cervical cancer patients following primary surgical treatment. METHODS: The medical records of 116 cervical cancer patients treated with primary surgical treatment wer...

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Autores principales: Yang, Sun-Hye, Kong, Su-Kyoung, Lee, Seung-Ho, Lim, So-Yi, Park, Chan-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245343/
https://www.ncbi.nlm.nih.gov/pubmed/25469338
http://dx.doi.org/10.5468/ogs.2014.57.6.492
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author Yang, Sun-Hye
Kong, Su-Kyoung
Lee, Seung-Ho
Lim, So-Yi
Park, Chan-Yong
author_facet Yang, Sun-Hye
Kong, Su-Kyoung
Lee, Seung-Ho
Lim, So-Yi
Park, Chan-Yong
author_sort Yang, Sun-Hye
collection PubMed
description OBJECTIVE: This study evaluates the effect of the specific human papillomavirus (HPV) genotype as a prognostic factor in stage I-IIA cervical cancer patients following primary surgical treatment. METHODS: The medical records of 116 cervical cancer patients treated with primary surgical treatment were reviewed. The HPV genotypes were categorized into following groups: negative and unclassified, HPV 16, HPV 18, and other high risk (HPV 31, 33, 35, 45, 51, 52, 56, and 58). RESULTS: Among the HPV genotypes, HPV 16 predominated (40.52%), followed by intermediate risk and unclassified (25%), HPV 18, 45, and 56 (17.24%) and negative (17.24%). In univariate analysis, HPV genotypes (P=0.03), parametrial spread (P=0.02), depth of invasion (DOI) (P<0.01) and lymph-vascular space invasion (P=0.02) were significantly associated with progression free survival (PFS). In multivariate analysis, HPV 18 (hazard ratio [HR], 5.2; 95% confidence interval [CI], 1.29 to 20.90; P=0.02) and ≥one half of DOI (HR, 5.4; 95% CI, 1.08 to 27.31; P=0.04) were significantly associated with PFS. HPV genotypes are not significantly associated with overall survival. CONCLUSION: HPV 18 was a poor prognostic factor for the PFS in stage I-IIA cervical cancer patients following primary surgical treatment. Careful long-term observation and regular exams are recommended for cervical cancer patients with HPV 18 compared to those with other HPV genotypes.
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spelling pubmed-42453432014-12-02 Human papillomavirus 18 as a poor prognostic factor in stage I-IIA cervical cancer following primary surgical treatment Yang, Sun-Hye Kong, Su-Kyoung Lee, Seung-Ho Lim, So-Yi Park, Chan-Yong Obstet Gynecol Sci Original Article OBJECTIVE: This study evaluates the effect of the specific human papillomavirus (HPV) genotype as a prognostic factor in stage I-IIA cervical cancer patients following primary surgical treatment. METHODS: The medical records of 116 cervical cancer patients treated with primary surgical treatment were reviewed. The HPV genotypes were categorized into following groups: negative and unclassified, HPV 16, HPV 18, and other high risk (HPV 31, 33, 35, 45, 51, 52, 56, and 58). RESULTS: Among the HPV genotypes, HPV 16 predominated (40.52%), followed by intermediate risk and unclassified (25%), HPV 18, 45, and 56 (17.24%) and negative (17.24%). In univariate analysis, HPV genotypes (P=0.03), parametrial spread (P=0.02), depth of invasion (DOI) (P<0.01) and lymph-vascular space invasion (P=0.02) were significantly associated with progression free survival (PFS). In multivariate analysis, HPV 18 (hazard ratio [HR], 5.2; 95% confidence interval [CI], 1.29 to 20.90; P=0.02) and ≥one half of DOI (HR, 5.4; 95% CI, 1.08 to 27.31; P=0.04) were significantly associated with PFS. HPV genotypes are not significantly associated with overall survival. CONCLUSION: HPV 18 was a poor prognostic factor for the PFS in stage I-IIA cervical cancer patients following primary surgical treatment. Careful long-term observation and regular exams are recommended for cervical cancer patients with HPV 18 compared to those with other HPV genotypes. Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2014-11 2014-11-20 /pmc/articles/PMC4245343/ /pubmed/25469338 http://dx.doi.org/10.5468/ogs.2014.57.6.492 Text en Copyright © 2014 Korean Society of Obstetrics and Gynecology http://creativecommons.org/licenses/by-nc/3.0/ Articles published in Obstet Gynecol Sci are open-access, distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yang, Sun-Hye
Kong, Su-Kyoung
Lee, Seung-Ho
Lim, So-Yi
Park, Chan-Yong
Human papillomavirus 18 as a poor prognostic factor in stage I-IIA cervical cancer following primary surgical treatment
title Human papillomavirus 18 as a poor prognostic factor in stage I-IIA cervical cancer following primary surgical treatment
title_full Human papillomavirus 18 as a poor prognostic factor in stage I-IIA cervical cancer following primary surgical treatment
title_fullStr Human papillomavirus 18 as a poor prognostic factor in stage I-IIA cervical cancer following primary surgical treatment
title_full_unstemmed Human papillomavirus 18 as a poor prognostic factor in stage I-IIA cervical cancer following primary surgical treatment
title_short Human papillomavirus 18 as a poor prognostic factor in stage I-IIA cervical cancer following primary surgical treatment
title_sort human papillomavirus 18 as a poor prognostic factor in stage i-iia cervical cancer following primary surgical treatment
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245343/
https://www.ncbi.nlm.nih.gov/pubmed/25469338
http://dx.doi.org/10.5468/ogs.2014.57.6.492
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