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Prevalence of thromogenic gene mutations in women with recurrent miscarriage: A retrospective study of 1,507 patients
OBJECTIVE: Thromogenic gene mutations has been thought to be associated with recurrent pregnancy loss in women in Turkey. The aim of this study was to investigate the prevalence of thromogenic gene mutations such as factor V Leiden (FVL, G1691T), prothrombin (G20210A), and the methylene tetrahydrofo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245346/ https://www.ncbi.nlm.nih.gov/pubmed/25469341 http://dx.doi.org/10.5468/ogs.2014.57.6.513 |
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author | Incebiyik, Adnan Hilali, Nese Gul Camuzcuoglu, Aysun Camuzcuoglu, Hakan Akbas, Halit Kilic, Avni Vural, Mehmet |
author_facet | Incebiyik, Adnan Hilali, Nese Gul Camuzcuoglu, Aysun Camuzcuoglu, Hakan Akbas, Halit Kilic, Avni Vural, Mehmet |
author_sort | Incebiyik, Adnan |
collection | PubMed |
description | OBJECTIVE: Thromogenic gene mutations has been thought to be associated with recurrent pregnancy loss in women in Turkey. The aim of this study was to investigate the prevalence of thromogenic gene mutations such as factor V Leiden (FVL, G1691T), prothrombin (G20210A), and the methylene tetrahydrofolate reductase (MTHFR, C677T) mutation in women with recurrent pregnancy loss. METHODS: This descriptive study was carried out in the Department of Obstetrics and Gynaecology, Harran University School of Medicine, and included a total of 1,507 women with histories of recurrent pregnancy loss between January 2010 and June 2013. The mutations were assessed by using the polymerase chain reaction. RESULTS: The homozygous mutation frequencies of FVL, prothrombin, and MTHFR were found to be 3 (0.20%), 0 and 125 (8.29%), and the heterozygous mutation frequencies were 83 (5.51%), 61 (4.05%), and 612 (40.61%), respectively. Among the 86 FVL mutation patients, 38 also had accompanying prothrombin and MTHFR mutations. CONCLUSION: Since the homozygous forms of the FVL-prothrombin gene mutations have low incidences and MTHFR mutation is similar to a healthy population, preconceptional thromogenic gene mutations screening seems to be controversial. |
format | Online Article Text |
id | pubmed-4245346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-42453462014-12-02 Prevalence of thromogenic gene mutations in women with recurrent miscarriage: A retrospective study of 1,507 patients Incebiyik, Adnan Hilali, Nese Gul Camuzcuoglu, Aysun Camuzcuoglu, Hakan Akbas, Halit Kilic, Avni Vural, Mehmet Obstet Gynecol Sci Original Article OBJECTIVE: Thromogenic gene mutations has been thought to be associated with recurrent pregnancy loss in women in Turkey. The aim of this study was to investigate the prevalence of thromogenic gene mutations such as factor V Leiden (FVL, G1691T), prothrombin (G20210A), and the methylene tetrahydrofolate reductase (MTHFR, C677T) mutation in women with recurrent pregnancy loss. METHODS: This descriptive study was carried out in the Department of Obstetrics and Gynaecology, Harran University School of Medicine, and included a total of 1,507 women with histories of recurrent pregnancy loss between January 2010 and June 2013. The mutations were assessed by using the polymerase chain reaction. RESULTS: The homozygous mutation frequencies of FVL, prothrombin, and MTHFR were found to be 3 (0.20%), 0 and 125 (8.29%), and the heterozygous mutation frequencies were 83 (5.51%), 61 (4.05%), and 612 (40.61%), respectively. Among the 86 FVL mutation patients, 38 also had accompanying prothrombin and MTHFR mutations. CONCLUSION: Since the homozygous forms of the FVL-prothrombin gene mutations have low incidences and MTHFR mutation is similar to a healthy population, preconceptional thromogenic gene mutations screening seems to be controversial. Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2014-11 2014-11-20 /pmc/articles/PMC4245346/ /pubmed/25469341 http://dx.doi.org/10.5468/ogs.2014.57.6.513 Text en Copyright © 2014 Korean Society of Obstetrics and Gynecology http://creativecommons.org/licenses/by-nc/3.0/ Articles published in Obstet Gynecol Sci are open-access, distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Incebiyik, Adnan Hilali, Nese Gul Camuzcuoglu, Aysun Camuzcuoglu, Hakan Akbas, Halit Kilic, Avni Vural, Mehmet Prevalence of thromogenic gene mutations in women with recurrent miscarriage: A retrospective study of 1,507 patients |
title | Prevalence of thromogenic gene mutations in women with recurrent miscarriage: A retrospective study of 1,507 patients |
title_full | Prevalence of thromogenic gene mutations in women with recurrent miscarriage: A retrospective study of 1,507 patients |
title_fullStr | Prevalence of thromogenic gene mutations in women with recurrent miscarriage: A retrospective study of 1,507 patients |
title_full_unstemmed | Prevalence of thromogenic gene mutations in women with recurrent miscarriage: A retrospective study of 1,507 patients |
title_short | Prevalence of thromogenic gene mutations in women with recurrent miscarriage: A retrospective study of 1,507 patients |
title_sort | prevalence of thromogenic gene mutations in women with recurrent miscarriage: a retrospective study of 1,507 patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245346/ https://www.ncbi.nlm.nih.gov/pubmed/25469341 http://dx.doi.org/10.5468/ogs.2014.57.6.513 |
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