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Bone mineral density in women with polycystic ovary syndrome

PURPOSE: PCOS is a complex disorder and various features of this disorder may have great importance for bone metabolism. The aim of the study was to determine the relationship between existing hormonal disorders, and bone mineral density (BMD) in young women with PCOS. METHODS: 69 reproductive-aged...

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Autores principales: Katulski, K., Slawek, S., Czyzyk, A., Podfigurna-Stopa, A., Paczkowska, K., Ignaszak, N., Podkowa, N., Meczekalski, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245449/
https://www.ncbi.nlm.nih.gov/pubmed/25245338
http://dx.doi.org/10.1007/s40618-014-0175-5
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author Katulski, K.
Slawek, S.
Czyzyk, A.
Podfigurna-Stopa, A.
Paczkowska, K.
Ignaszak, N.
Podkowa, N.
Meczekalski, B.
author_facet Katulski, K.
Slawek, S.
Czyzyk, A.
Podfigurna-Stopa, A.
Paczkowska, K.
Ignaszak, N.
Podkowa, N.
Meczekalski, B.
author_sort Katulski, K.
collection PubMed
description PURPOSE: PCOS is a complex disorder and various features of this disorder may have great importance for bone metabolism. The aim of the study was to determine the relationship between existing hormonal disorders, and bone mineral density (BMD) in young women with PCOS. METHODS: 69 reproductive-aged PCOS women and 30 age-matched healthy controls were enrolled to the study women. In each individual we assessed the body mass index (BMI). We evaluated the serum concentrations of: gonadotropins, prolactin (PRL), estradiol (E2), dehydroepiandrosterone sulfate (DHEAS), testosterone (T), thyroid stimulating hormone (TSH), free thyroxine (fT4). We used the Homeostatic Model Assessment–Insulin Resistance Index (HOMA–IR) to diagnose insulin resistance. Bone mineral density in the lumbar spine was measured by dual-energy X-ray absorptiometry (DXA). RESULTS: The PCOS women had lower BMD values as compared to the controls (1.057 ± 0.1260 vs. 1.210 ± 0.1805 g/cm(2), p < 0.0002). In the analysis of PCOS patients according to BMI, only in the subgroup of the normal weight PCOS we find significantly lower BMD in comparison to controls (p = 0.0049). In patients with PCOS, BMD was positively correlated with insulin concentration and HOMA–IR. In the controls Z-score values were positively correlated with insulin concentration and HOMA–IR. CONCLUSIONS: The deleterious effect of estrogen deficiency on bones in PCOS is not balanced by androgen overproduction. Women with PCOS had significantly lower BMD of the lumbar spine compared to controls. Insulin seems to be one of the most important positive bone growth stimulators.
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spelling pubmed-42454492014-12-03 Bone mineral density in women with polycystic ovary syndrome Katulski, K. Slawek, S. Czyzyk, A. Podfigurna-Stopa, A. Paczkowska, K. Ignaszak, N. Podkowa, N. Meczekalski, B. J Endocrinol Invest Original Article PURPOSE: PCOS is a complex disorder and various features of this disorder may have great importance for bone metabolism. The aim of the study was to determine the relationship between existing hormonal disorders, and bone mineral density (BMD) in young women with PCOS. METHODS: 69 reproductive-aged PCOS women and 30 age-matched healthy controls were enrolled to the study women. In each individual we assessed the body mass index (BMI). We evaluated the serum concentrations of: gonadotropins, prolactin (PRL), estradiol (E2), dehydroepiandrosterone sulfate (DHEAS), testosterone (T), thyroid stimulating hormone (TSH), free thyroxine (fT4). We used the Homeostatic Model Assessment–Insulin Resistance Index (HOMA–IR) to diagnose insulin resistance. Bone mineral density in the lumbar spine was measured by dual-energy X-ray absorptiometry (DXA). RESULTS: The PCOS women had lower BMD values as compared to the controls (1.057 ± 0.1260 vs. 1.210 ± 0.1805 g/cm(2), p < 0.0002). In the analysis of PCOS patients according to BMI, only in the subgroup of the normal weight PCOS we find significantly lower BMD in comparison to controls (p = 0.0049). In patients with PCOS, BMD was positively correlated with insulin concentration and HOMA–IR. In the controls Z-score values were positively correlated with insulin concentration and HOMA–IR. CONCLUSIONS: The deleterious effect of estrogen deficiency on bones in PCOS is not balanced by androgen overproduction. Women with PCOS had significantly lower BMD of the lumbar spine compared to controls. Insulin seems to be one of the most important positive bone growth stimulators. Springer International Publishing 2014-09-23 2014 /pmc/articles/PMC4245449/ /pubmed/25245338 http://dx.doi.org/10.1007/s40618-014-0175-5 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Katulski, K.
Slawek, S.
Czyzyk, A.
Podfigurna-Stopa, A.
Paczkowska, K.
Ignaszak, N.
Podkowa, N.
Meczekalski, B.
Bone mineral density in women with polycystic ovary syndrome
title Bone mineral density in women with polycystic ovary syndrome
title_full Bone mineral density in women with polycystic ovary syndrome
title_fullStr Bone mineral density in women with polycystic ovary syndrome
title_full_unstemmed Bone mineral density in women with polycystic ovary syndrome
title_short Bone mineral density in women with polycystic ovary syndrome
title_sort bone mineral density in women with polycystic ovary syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245449/
https://www.ncbi.nlm.nih.gov/pubmed/25245338
http://dx.doi.org/10.1007/s40618-014-0175-5
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