IMP-1 encoded by a novel Tn402-like class 1 integron in clinical Achromobacter xylosoxidans, China

Achromobacter xylosoxidans strain A22732 is isolated from a pneumonia patient in China and produces carbapenemases OXA-114e and IMP-1, which are encoded by chromosome and plasmid, respectively, and confer resistance to multiple ß-lactam antibiotics including carbapenems. The bla(IMP-1) gene together...

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Autores principales: Chen, Zhenhong, Fang, Haihong, Wang, Li, Sun, Fengjun, Wang, Yong, Yin, Zhe, Yang, Huiying, Yang, Wenhui, Wang, Jie, Xia, Peiyuan, Zhou, Dongsheng, Liu, Changting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245530/
https://www.ncbi.nlm.nih.gov/pubmed/25428613
http://dx.doi.org/10.1038/srep07212
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author Chen, Zhenhong
Fang, Haihong
Wang, Li
Sun, Fengjun
Wang, Yong
Yin, Zhe
Yang, Huiying
Yang, Wenhui
Wang, Jie
Xia, Peiyuan
Zhou, Dongsheng
Liu, Changting
author_facet Chen, Zhenhong
Fang, Haihong
Wang, Li
Sun, Fengjun
Wang, Yong
Yin, Zhe
Yang, Huiying
Yang, Wenhui
Wang, Jie
Xia, Peiyuan
Zhou, Dongsheng
Liu, Changting
author_sort Chen, Zhenhong
collection PubMed
description Achromobacter xylosoxidans strain A22732 is isolated from a pneumonia patient in China and produces carbapenemases OXA-114e and IMP-1, which are encoded by chromosome and plasmid, respectively, and confer resistance to multiple ß-lactam antibiotics including carbapenems. The bla(IMP-1) gene together with aacA7 and orfE is captured by a novel Tn402-like class 1 integron in a conjugative IncP-1ß plasmid. In addition to the intrinsic integron promoter PcW, there is still a bla(IMP-1) gene cassette-specific promoter. This is the first report of carbapenemase-encoding IncP-1ß plasmid in clinical bacterial isolate.
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spelling pubmed-42455302014-12-05 IMP-1 encoded by a novel Tn402-like class 1 integron in clinical Achromobacter xylosoxidans, China Chen, Zhenhong Fang, Haihong Wang, Li Sun, Fengjun Wang, Yong Yin, Zhe Yang, Huiying Yang, Wenhui Wang, Jie Xia, Peiyuan Zhou, Dongsheng Liu, Changting Sci Rep Article Achromobacter xylosoxidans strain A22732 is isolated from a pneumonia patient in China and produces carbapenemases OXA-114e and IMP-1, which are encoded by chromosome and plasmid, respectively, and confer resistance to multiple ß-lactam antibiotics including carbapenems. The bla(IMP-1) gene together with aacA7 and orfE is captured by a novel Tn402-like class 1 integron in a conjugative IncP-1ß plasmid. In addition to the intrinsic integron promoter PcW, there is still a bla(IMP-1) gene cassette-specific promoter. This is the first report of carbapenemase-encoding IncP-1ß plasmid in clinical bacterial isolate. Nature Publishing Group 2014-11-27 /pmc/articles/PMC4245530/ /pubmed/25428613 http://dx.doi.org/10.1038/srep07212 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Chen, Zhenhong
Fang, Haihong
Wang, Li
Sun, Fengjun
Wang, Yong
Yin, Zhe
Yang, Huiying
Yang, Wenhui
Wang, Jie
Xia, Peiyuan
Zhou, Dongsheng
Liu, Changting
IMP-1 encoded by a novel Tn402-like class 1 integron in clinical Achromobacter xylosoxidans, China
title IMP-1 encoded by a novel Tn402-like class 1 integron in clinical Achromobacter xylosoxidans, China
title_full IMP-1 encoded by a novel Tn402-like class 1 integron in clinical Achromobacter xylosoxidans, China
title_fullStr IMP-1 encoded by a novel Tn402-like class 1 integron in clinical Achromobacter xylosoxidans, China
title_full_unstemmed IMP-1 encoded by a novel Tn402-like class 1 integron in clinical Achromobacter xylosoxidans, China
title_short IMP-1 encoded by a novel Tn402-like class 1 integron in clinical Achromobacter xylosoxidans, China
title_sort imp-1 encoded by a novel tn402-like class 1 integron in clinical achromobacter xylosoxidans, china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245530/
https://www.ncbi.nlm.nih.gov/pubmed/25428613
http://dx.doi.org/10.1038/srep07212
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