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Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice

Codonopsis lanceolata extract (CLE) has been used in traditional medicine in the Asian-Pacific region for the treatment of bronchitis, cough, and inflammation. However, it is still unclear whether obesity in mice can be altered by diet supplementation with CLE. To investigate whether CLE could have...

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Autores principales: Lee, Jong Seok, Kim, Kui-Jin, Kim, Young-Hyun, Kim, Dan-Bi, Shin, Gi-Hae, Cho, Ju-Hyun, Kim, Bong Kyun, Lee, Boo-Yong, Lee, Ok-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245555/
https://www.ncbi.nlm.nih.gov/pubmed/25353662
http://dx.doi.org/10.3390/nu6114663
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author Lee, Jong Seok
Kim, Kui-Jin
Kim, Young-Hyun
Kim, Dan-Bi
Shin, Gi-Hae
Cho, Ju-Hyun
Kim, Bong Kyun
Lee, Boo-Yong
Lee, Ok-Hwan
author_facet Lee, Jong Seok
Kim, Kui-Jin
Kim, Young-Hyun
Kim, Dan-Bi
Shin, Gi-Hae
Cho, Ju-Hyun
Kim, Bong Kyun
Lee, Boo-Yong
Lee, Ok-Hwan
author_sort Lee, Jong Seok
collection PubMed
description Codonopsis lanceolata extract (CLE) has been used in traditional medicine in the Asian-Pacific region for the treatment of bronchitis, cough, and inflammation. However, it is still unclear whether obesity in mice can be altered by diet supplementation with CLE. To investigate whether CLE could have preventative effects on high fat diet (HFD)-induced obesity, male C57BL/6 mice were placed on either a normal chow diet, 60% HFD, or a HFD supplemented with CLE (60, 180, and 360 mg/kg/day) for 12 weeks. CLE decreased body weight and subcutaneous and visceral fat weights in HFD-induced obese mice. CLE group mice showed lower fat accumulation and a smaller adipocyte area in the adipose tissue compared with the HFD group mice. CLE group mice exhibited lower serum levels of triglycerides, total cholesterol, low density lipoprotein (LDL), glucose, and insulin compared with the HFD group mice. In addition, CLE decreased liver weight and lowered the increase in aspartate aminotransferase (AST) and alanine transaminase (ALT) levels in HFD-induced obese mice. These results indicate that CLE can inhibit the development of diet-induced obesity and hyperlipidemia in C57BL/6 mice.
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spelling pubmed-42455552014-12-01 Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice Lee, Jong Seok Kim, Kui-Jin Kim, Young-Hyun Kim, Dan-Bi Shin, Gi-Hae Cho, Ju-Hyun Kim, Bong Kyun Lee, Boo-Yong Lee, Ok-Hwan Nutrients Article Codonopsis lanceolata extract (CLE) has been used in traditional medicine in the Asian-Pacific region for the treatment of bronchitis, cough, and inflammation. However, it is still unclear whether obesity in mice can be altered by diet supplementation with CLE. To investigate whether CLE could have preventative effects on high fat diet (HFD)-induced obesity, male C57BL/6 mice were placed on either a normal chow diet, 60% HFD, or a HFD supplemented with CLE (60, 180, and 360 mg/kg/day) for 12 weeks. CLE decreased body weight and subcutaneous and visceral fat weights in HFD-induced obese mice. CLE group mice showed lower fat accumulation and a smaller adipocyte area in the adipose tissue compared with the HFD group mice. CLE group mice exhibited lower serum levels of triglycerides, total cholesterol, low density lipoprotein (LDL), glucose, and insulin compared with the HFD group mice. In addition, CLE decreased liver weight and lowered the increase in aspartate aminotransferase (AST) and alanine transaminase (ALT) levels in HFD-induced obese mice. These results indicate that CLE can inhibit the development of diet-induced obesity and hyperlipidemia in C57BL/6 mice. MDPI 2014-10-28 /pmc/articles/PMC4245555/ /pubmed/25353662 http://dx.doi.org/10.3390/nu6114663 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Jong Seok
Kim, Kui-Jin
Kim, Young-Hyun
Kim, Dan-Bi
Shin, Gi-Hae
Cho, Ju-Hyun
Kim, Bong Kyun
Lee, Boo-Yong
Lee, Ok-Hwan
Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice
title Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice
title_full Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice
title_fullStr Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice
title_full_unstemmed Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice
title_short Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice
title_sort codonopsis lanceolata extract prevents diet-induced obesity in c57bl/6 mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245555/
https://www.ncbi.nlm.nih.gov/pubmed/25353662
http://dx.doi.org/10.3390/nu6114663
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