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Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice
Codonopsis lanceolata extract (CLE) has been used in traditional medicine in the Asian-Pacific region for the treatment of bronchitis, cough, and inflammation. However, it is still unclear whether obesity in mice can be altered by diet supplementation with CLE. To investigate whether CLE could have...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245555/ https://www.ncbi.nlm.nih.gov/pubmed/25353662 http://dx.doi.org/10.3390/nu6114663 |
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author | Lee, Jong Seok Kim, Kui-Jin Kim, Young-Hyun Kim, Dan-Bi Shin, Gi-Hae Cho, Ju-Hyun Kim, Bong Kyun Lee, Boo-Yong Lee, Ok-Hwan |
author_facet | Lee, Jong Seok Kim, Kui-Jin Kim, Young-Hyun Kim, Dan-Bi Shin, Gi-Hae Cho, Ju-Hyun Kim, Bong Kyun Lee, Boo-Yong Lee, Ok-Hwan |
author_sort | Lee, Jong Seok |
collection | PubMed |
description | Codonopsis lanceolata extract (CLE) has been used in traditional medicine in the Asian-Pacific region for the treatment of bronchitis, cough, and inflammation. However, it is still unclear whether obesity in mice can be altered by diet supplementation with CLE. To investigate whether CLE could have preventative effects on high fat diet (HFD)-induced obesity, male C57BL/6 mice were placed on either a normal chow diet, 60% HFD, or a HFD supplemented with CLE (60, 180, and 360 mg/kg/day) for 12 weeks. CLE decreased body weight and subcutaneous and visceral fat weights in HFD-induced obese mice. CLE group mice showed lower fat accumulation and a smaller adipocyte area in the adipose tissue compared with the HFD group mice. CLE group mice exhibited lower serum levels of triglycerides, total cholesterol, low density lipoprotein (LDL), glucose, and insulin compared with the HFD group mice. In addition, CLE decreased liver weight and lowered the increase in aspartate aminotransferase (AST) and alanine transaminase (ALT) levels in HFD-induced obese mice. These results indicate that CLE can inhibit the development of diet-induced obesity and hyperlipidemia in C57BL/6 mice. |
format | Online Article Text |
id | pubmed-4245555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42455552014-12-01 Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice Lee, Jong Seok Kim, Kui-Jin Kim, Young-Hyun Kim, Dan-Bi Shin, Gi-Hae Cho, Ju-Hyun Kim, Bong Kyun Lee, Boo-Yong Lee, Ok-Hwan Nutrients Article Codonopsis lanceolata extract (CLE) has been used in traditional medicine in the Asian-Pacific region for the treatment of bronchitis, cough, and inflammation. However, it is still unclear whether obesity in mice can be altered by diet supplementation with CLE. To investigate whether CLE could have preventative effects on high fat diet (HFD)-induced obesity, male C57BL/6 mice were placed on either a normal chow diet, 60% HFD, or a HFD supplemented with CLE (60, 180, and 360 mg/kg/day) for 12 weeks. CLE decreased body weight and subcutaneous and visceral fat weights in HFD-induced obese mice. CLE group mice showed lower fat accumulation and a smaller adipocyte area in the adipose tissue compared with the HFD group mice. CLE group mice exhibited lower serum levels of triglycerides, total cholesterol, low density lipoprotein (LDL), glucose, and insulin compared with the HFD group mice. In addition, CLE decreased liver weight and lowered the increase in aspartate aminotransferase (AST) and alanine transaminase (ALT) levels in HFD-induced obese mice. These results indicate that CLE can inhibit the development of diet-induced obesity and hyperlipidemia in C57BL/6 mice. MDPI 2014-10-28 /pmc/articles/PMC4245555/ /pubmed/25353662 http://dx.doi.org/10.3390/nu6114663 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Jong Seok Kim, Kui-Jin Kim, Young-Hyun Kim, Dan-Bi Shin, Gi-Hae Cho, Ju-Hyun Kim, Bong Kyun Lee, Boo-Yong Lee, Ok-Hwan Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice |
title | Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice |
title_full | Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice |
title_fullStr | Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice |
title_full_unstemmed | Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice |
title_short | Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice |
title_sort | codonopsis lanceolata extract prevents diet-induced obesity in c57bl/6 mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245555/ https://www.ncbi.nlm.nih.gov/pubmed/25353662 http://dx.doi.org/10.3390/nu6114663 |
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