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Oxidative Damage and Inflammation in Obese Diabetic Emirati Subjects

Visceral obesity is more common in the Arab population and more closely related to morbidity, including diabetes and related cardiovascular diseases (CVD). Possible mechanisms that link visceral fat/obesity to diabetes and CVD complications include inflammation and increased oxidative stress; howeve...

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Autores principales: Gariballa, Salah, Kosanovic, Melita, Yasin, Javed, El Essa, Awad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245568/
https://www.ncbi.nlm.nih.gov/pubmed/25375631
http://dx.doi.org/10.3390/nu6114872
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author Gariballa, Salah
Kosanovic, Melita
Yasin, Javed
El Essa, Awad
author_facet Gariballa, Salah
Kosanovic, Melita
Yasin, Javed
El Essa, Awad
author_sort Gariballa, Salah
collection PubMed
description Visceral obesity is more common in the Arab population and more closely related to morbidity, including diabetes and related cardiovascular diseases (CVD). Possible mechanisms that link visceral fat/obesity to diabetes and CVD complications include inflammation and increased oxidative stress; however, few data are available from the Arab population. Our aim was to determine whether increased adiposity in obese diabetic United Arab Emirates citizens is associated with sub-clinical inflammation and/or increased oxidative stress. A hundred diabetic patients who were part of a randomized controlled trial of nutritional supplements had their baseline characteristics assessed from anthropometric and clinical data following informed written consent. We used WHO figures to classify general and central obesity. Fasting blood samples were collected for the measurement of antioxidants and markers of oxidative damage and inflammation. We found that increased adiposity measured by both body mass index and waist circumference was associated with increased C-reactive protein (CRP) and decreased vitamin C after adjusting for age, duration and treatment of diabetes (p < 0.05). Although there is a clear trend of increased inflammatory markers, notably CRP, and decreased antioxidants with increased BMI and waist circumference in both men and women, the results are statistically significant for women only. CRP were also inversely associated with HDL. Overall, we found that BMI underestimates the rates of obesity compared to waist circumference and that increased adiposity is associated with increased inflammation and decreased HDL and antioxidant status.
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spelling pubmed-42455682014-12-01 Oxidative Damage and Inflammation in Obese Diabetic Emirati Subjects Gariballa, Salah Kosanovic, Melita Yasin, Javed El Essa, Awad Nutrients Communication Visceral obesity is more common in the Arab population and more closely related to morbidity, including diabetes and related cardiovascular diseases (CVD). Possible mechanisms that link visceral fat/obesity to diabetes and CVD complications include inflammation and increased oxidative stress; however, few data are available from the Arab population. Our aim was to determine whether increased adiposity in obese diabetic United Arab Emirates citizens is associated with sub-clinical inflammation and/or increased oxidative stress. A hundred diabetic patients who were part of a randomized controlled trial of nutritional supplements had their baseline characteristics assessed from anthropometric and clinical data following informed written consent. We used WHO figures to classify general and central obesity. Fasting blood samples were collected for the measurement of antioxidants and markers of oxidative damage and inflammation. We found that increased adiposity measured by both body mass index and waist circumference was associated with increased C-reactive protein (CRP) and decreased vitamin C after adjusting for age, duration and treatment of diabetes (p < 0.05). Although there is a clear trend of increased inflammatory markers, notably CRP, and decreased antioxidants with increased BMI and waist circumference in both men and women, the results are statistically significant for women only. CRP were also inversely associated with HDL. Overall, we found that BMI underestimates the rates of obesity compared to waist circumference and that increased adiposity is associated with increased inflammation and decreased HDL and antioxidant status. MDPI 2014-11-04 /pmc/articles/PMC4245568/ /pubmed/25375631 http://dx.doi.org/10.3390/nu6114872 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Gariballa, Salah
Kosanovic, Melita
Yasin, Javed
El Essa, Awad
Oxidative Damage and Inflammation in Obese Diabetic Emirati Subjects
title Oxidative Damage and Inflammation in Obese Diabetic Emirati Subjects
title_full Oxidative Damage and Inflammation in Obese Diabetic Emirati Subjects
title_fullStr Oxidative Damage and Inflammation in Obese Diabetic Emirati Subjects
title_full_unstemmed Oxidative Damage and Inflammation in Obese Diabetic Emirati Subjects
title_short Oxidative Damage and Inflammation in Obese Diabetic Emirati Subjects
title_sort oxidative damage and inflammation in obese diabetic emirati subjects
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245568/
https://www.ncbi.nlm.nih.gov/pubmed/25375631
http://dx.doi.org/10.3390/nu6114872
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