No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure

Single nucleotide polymorphisms (SNPs) within the MIR137, TCF4, and ZNF804A genes show genome-wide association to schizophrenia. However, the biological basis for the associations is unknown. Here, we tested the effects of these genes on brain structure in 1300 healthy adults. Using volumetry and vo...

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Autores principales: Cousijn, Helena, Eissing, Marc, Fernández, Guillén, Fisher, Simon E., Franke, Barbara, Zwiers, Marcel, Harrison, Paul J., Arias-Vásquez, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Publisher B. V 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245712/
https://www.ncbi.nlm.nih.gov/pubmed/25217366
http://dx.doi.org/10.1016/j.schres.2014.08.007
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author Cousijn, Helena
Eissing, Marc
Fernández, Guillén
Fisher, Simon E.
Franke, Barbara
Zwiers, Marcel
Harrison, Paul J.
Arias-Vásquez, Alejandro
author_facet Cousijn, Helena
Eissing, Marc
Fernández, Guillén
Fisher, Simon E.
Franke, Barbara
Zwiers, Marcel
Harrison, Paul J.
Arias-Vásquez, Alejandro
author_sort Cousijn, Helena
collection PubMed
description Single nucleotide polymorphisms (SNPs) within the MIR137, TCF4, and ZNF804A genes show genome-wide association to schizophrenia. However, the biological basis for the associations is unknown. Here, we tested the effects of these genes on brain structure in 1300 healthy adults. Using volumetry and voxel-based morphometry, neither gene-wide effects—including the combined effect of the genes—nor single SNP effects—including specific psychosis risk SNPs—were found on total brain volume, grey matter, white matter, or hippocampal volume. These results suggest that the associations between these risk genes and schizophrenia are unlikely to be mediated via effects on macroscopic brain structure.
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spelling pubmed-42457122014-12-03 No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure Cousijn, Helena Eissing, Marc Fernández, Guillén Fisher, Simon E. Franke, Barbara Zwiers, Marcel Harrison, Paul J. Arias-Vásquez, Alejandro Schizophr Res Article Single nucleotide polymorphisms (SNPs) within the MIR137, TCF4, and ZNF804A genes show genome-wide association to schizophrenia. However, the biological basis for the associations is unknown. Here, we tested the effects of these genes on brain structure in 1300 healthy adults. Using volumetry and voxel-based morphometry, neither gene-wide effects—including the combined effect of the genes—nor single SNP effects—including specific psychosis risk SNPs—were found on total brain volume, grey matter, white matter, or hippocampal volume. These results suggest that the associations between these risk genes and schizophrenia are unlikely to be mediated via effects on macroscopic brain structure. Elsevier Science Publisher B. V 2014-11 /pmc/articles/PMC4245712/ /pubmed/25217366 http://dx.doi.org/10.1016/j.schres.2014.08.007 Text en © 2014 The Authors. Published by Elsevier B.V. https://creativecommons.org/licenses/by/3.0/This work is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/) .
spellingShingle Article
Cousijn, Helena
Eissing, Marc
Fernández, Guillén
Fisher, Simon E.
Franke, Barbara
Zwiers, Marcel
Harrison, Paul J.
Arias-Vásquez, Alejandro
No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure
title No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure
title_full No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure
title_fullStr No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure
title_full_unstemmed No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure
title_short No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure
title_sort no effect of schizophrenia risk genes mir137, tcf4, and znf804a on macroscopic brain structure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245712/
https://www.ncbi.nlm.nih.gov/pubmed/25217366
http://dx.doi.org/10.1016/j.schres.2014.08.007
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