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Development of a novel resin with antimicrobial properties for dental application

The adhesion of biofilm on dental prostheses is a prerequisite for the occurrence of oral diseases. OBJECTIVE: To assess the antimicrobial activity and the mechanical properties of an acrylic resin embedded with nanostructured silver vanadate (β-AgVO(3)). MATERIAL AND METHODS: The minimum inhibitory...

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Autores principales: de CASTRO, Denise Tornavoi, HOLTZ, Raphael Dias, ALVES, Oswaldo Luiz, WATANABE, Evandro, VALENTE, Mariana Lima da Costa, da SILVA, Cláudia Helena Lovato, dos REIS, Andréa Cândido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculdade de Odontologia de Bauru da Universidade de São Paulo 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245757/
https://www.ncbi.nlm.nih.gov/pubmed/25466477
http://dx.doi.org/10.1590/1678-775720130539
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author de CASTRO, Denise Tornavoi
HOLTZ, Raphael Dias
ALVES, Oswaldo Luiz
WATANABE, Evandro
VALENTE, Mariana Lima da Costa
da SILVA, Cláudia Helena Lovato
dos REIS, Andréa Cândido
author_facet de CASTRO, Denise Tornavoi
HOLTZ, Raphael Dias
ALVES, Oswaldo Luiz
WATANABE, Evandro
VALENTE, Mariana Lima da Costa
da SILVA, Cláudia Helena Lovato
dos REIS, Andréa Cândido
author_sort de CASTRO, Denise Tornavoi
collection PubMed
description The adhesion of biofilm on dental prostheses is a prerequisite for the occurrence of oral diseases. OBJECTIVE: To assess the antimicrobial activity and the mechanical properties of an acrylic resin embedded with nanostructured silver vanadate (β-AgVO(3)). MATERIAL AND METHODS: The minimum inhibitory concentration (MIC) of β-AgVO(3) was studied in relation to the species Staphylococcus aureus ATCC 25923, Streptococcus mutans ATCC 25175, Pseudomonas aeruginosa ATCC 27853, and Candida albicans ATCC 10231. The halo zone of inhibition method was performed in triplicate to determine the inhibitory effect of the modified self-curing acrylic resin Dencor Lay - Clássico(®). The surface hardness and compressive strength were examined. The specimens were prepared according to the percentage of β-AgVO(3) (0%-control, 0.5%, 1%, 2.5%, 5%, and 10%), with a sample size of 9x2 mm for surface hardness and antimicrobial activity tests, and 8x4 mm for the compression test. The values of the microbiologic analysis were compared and evaluated using the Kruskal-Wallis test (α=0.05); the mechanical analysis used the Shapiro-Wilk's tests, Levene's test, ANOVA (one-way), and Tukey's test (α=0.05). RESULTS: The addition of 10% β-AgVO(3) promoted antimicrobial activity against all strains. The antimicrobial effect was observed at a minimum concentration of 1% for P. aeruginosa, 2.5% for S. aureus, 5% for C. albicans, and 10% for S. mutans. Surface hardness and compressive strength increased significantly with the addition of 0.5% β-AgVO(3) (p<0.05). Higher rates of the nanomaterial did not alter the mechanical properties of the resin in comparison with the control group (p>0.05). CONCLUSIONS: The incorporation of β-AgVO(3) has the potential to promote antimicrobial activity in the acrylic resin. At reduced rates, it improves the mechanical properties, and, at higher rates, it does not promote changes in the control.
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spelling pubmed-42457572014-12-01 Development of a novel resin with antimicrobial properties for dental application de CASTRO, Denise Tornavoi HOLTZ, Raphael Dias ALVES, Oswaldo Luiz WATANABE, Evandro VALENTE, Mariana Lima da Costa da SILVA, Cláudia Helena Lovato dos REIS, Andréa Cândido J Appl Oral Sci Original Articles The adhesion of biofilm on dental prostheses is a prerequisite for the occurrence of oral diseases. OBJECTIVE: To assess the antimicrobial activity and the mechanical properties of an acrylic resin embedded with nanostructured silver vanadate (β-AgVO(3)). MATERIAL AND METHODS: The minimum inhibitory concentration (MIC) of β-AgVO(3) was studied in relation to the species Staphylococcus aureus ATCC 25923, Streptococcus mutans ATCC 25175, Pseudomonas aeruginosa ATCC 27853, and Candida albicans ATCC 10231. The halo zone of inhibition method was performed in triplicate to determine the inhibitory effect of the modified self-curing acrylic resin Dencor Lay - Clássico(®). The surface hardness and compressive strength were examined. The specimens were prepared according to the percentage of β-AgVO(3) (0%-control, 0.5%, 1%, 2.5%, 5%, and 10%), with a sample size of 9x2 mm for surface hardness and antimicrobial activity tests, and 8x4 mm for the compression test. The values of the microbiologic analysis were compared and evaluated using the Kruskal-Wallis test (α=0.05); the mechanical analysis used the Shapiro-Wilk's tests, Levene's test, ANOVA (one-way), and Tukey's test (α=0.05). RESULTS: The addition of 10% β-AgVO(3) promoted antimicrobial activity against all strains. The antimicrobial effect was observed at a minimum concentration of 1% for P. aeruginosa, 2.5% for S. aureus, 5% for C. albicans, and 10% for S. mutans. Surface hardness and compressive strength increased significantly with the addition of 0.5% β-AgVO(3) (p<0.05). Higher rates of the nanomaterial did not alter the mechanical properties of the resin in comparison with the control group (p>0.05). CONCLUSIONS: The incorporation of β-AgVO(3) has the potential to promote antimicrobial activity in the acrylic resin. At reduced rates, it improves the mechanical properties, and, at higher rates, it does not promote changes in the control. Faculdade de Odontologia de Bauru da Universidade de São Paulo 2014 /pmc/articles/PMC4245757/ /pubmed/25466477 http://dx.doi.org/10.1590/1678-775720130539 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
de CASTRO, Denise Tornavoi
HOLTZ, Raphael Dias
ALVES, Oswaldo Luiz
WATANABE, Evandro
VALENTE, Mariana Lima da Costa
da SILVA, Cláudia Helena Lovato
dos REIS, Andréa Cândido
Development of a novel resin with antimicrobial properties for dental application
title Development of a novel resin with antimicrobial properties for dental application
title_full Development of a novel resin with antimicrobial properties for dental application
title_fullStr Development of a novel resin with antimicrobial properties for dental application
title_full_unstemmed Development of a novel resin with antimicrobial properties for dental application
title_short Development of a novel resin with antimicrobial properties for dental application
title_sort development of a novel resin with antimicrobial properties for dental application
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245757/
https://www.ncbi.nlm.nih.gov/pubmed/25466477
http://dx.doi.org/10.1590/1678-775720130539
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