Cargando…

Preconditioning Human Mesenchymal Stem Cells with a Low Concentration of BMP2 Stimulates Proliferation and Osteogenic Differentiation In Vitro

Clinical trials using bone morphogenetic protein-2 (BMP2) for bone reconstruction have shown promising results. However, the relatively high concentration needed to be effective raises concerns for efficacy and safety. The aim of this study was to investigate the osteogenic effect of an alternative...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lysdahl, Helle, Baatrup, Anette, Foldager, Casper Bindzus, Bünger, Cody
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2014
Materias:	Original Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245882/ https://www.ncbi.nlm.nih.gov/pubmed/25469313 http://dx.doi.org/10.1089/biores.2014.0044

Ejemplares similares

Dental pulp-derived stromal cells exhibit a higher osteogenic potency than bone marrow-derived stromal cells in vitro and in a porcine critical-size bone defect model
por: Jensen, Jonas, et al.
Publicado: (2016)

Improvement of Distribution and Osteogenic Differentiation of Human Mesenchymal Stem Cells by Hyaluronic Acid and β-Tricalcium Phosphate-Coated Polymeric Scaffold In Vitro
por: Chen, Muwan, et al.
Publicado: (2015)

Symptomatic lumbosacral transitional vertebra: a review of the current literature and clinical outcomes following steroid injection or surgical intervention
por: Holm, Emil Kongsted, et al.
Publicado: (2017)

Validation of suitable house keeping genes for hypoxia-cultured human chondrocytes
por: Foldager, Casper Bindzus, et al.
Publicado: (2009)

Use of Carboxymethyl Cellulose and Collagen Carrier with Equine Bone Lyophilisate Suggests Late Onset Bone Regenerative Effect in a Humerus Drill Defect – A Pilot Study in Six Sheep
por: Jensen, Jonas, et al.
Publicado: (2010)

Patients Scheduled for Chondrocyte Implantation Treatment with MACI Have Larger Defects than Those Enrolled in Clinical Trials
por: Foldager, Casper Bindzus, et al.
Publicado: (2015)

Non-invasive cell tracking of SPIO labeled cells in an intrinsic regenerative environment: The axolotl limb
por: Lauridsen, Henrik, et al.
Publicado: (2018)

A Stereological Method for the Quantitative Evaluation of Cartilage Repair Tissue
por: Foldager, Casper Bindzus, et al.
Publicado: (2015)

Cell Seeding Densities in Autologous Chondrocyte Implantation Techniques for Cartilage Repair
por: Foldager, Casper Bindzus, et al.
Publicado: (2012)

Autologous Dual-Tissue Transplantation for Osteochondral Repair: Early Clinical and Radiological Results
por: Christensen, Bjørn Borsøe, et al.
Publicado: (2015)

Osteogenic Potential of Sheep Mesenchymal Stem Cells Preconditioned with BMP-2 and FGF-2 and Seeded on an nHAP-Coated PCL/HAP/β-TCP Scaffold
por: Stamnitz, Sandra, et al.
Publicado: (2022)

In vitro proliferation and osteogenic differentiation of mesenchymal stem cells on nanoporous alumina
por: Song, Yuanhui, et al.
Publicado: (2013)

Distribution of Basement Membrane Molecules, Laminin and Collagen Type IV, in Normal and Degenerated Cartilage Tissues
por: Foldager, Casper Bindzus, et al.
Publicado: (2014)

Biological Characteristics and Osteogenic Differentiation of Ovine Bone Marrow Derived Mesenchymal Stem Cells Stimulated with FGF-2 and BMP-2
por: Gromolak, Sandra, et al.
Publicado: (2020)

Combined 3D and hypoxic culture improves cartilage-specific gene expression in human chondrocytes
por: Foldager, Casper B, et al.
Publicado: (2011)

Retinoic Acids Potentiate BMP9-Induced Osteogenic Differentiation of Mesenchymal Progenitor Cells
por: Zhang, Wenli, et al.
Publicado: (2010)

Activation of JNKs is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells
por: Zhao, Yan-fang, et al.
Publicado: (2013)

SIRT6 promotes osteogenic differentiation of mesenchymal stem cells through BMP signaling
por: Zhang, Ping, et al.
Publicado: (2017)

BMP-2 promotes osteogenic differentiation of mesenchymal stem cells by enhancing mitochondrial activity
por: Li, Yinan, et al.
Publicado: (2022)

Resveratrol Synergistically Promotes BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells
por: Wang, Yonghui, et al.
Publicado: (2022)

Hedgehog signaling is involved in the BMP9-induced osteogenic differentiation of mesenchymal stem cells
por: Li, Li, et al.
Publicado: (2023)

IGF1 potentiates BMP9-induced osteogenic differentiation in mesenchymal stem cells through the enhancement of BMP/Smad signaling
por: Chen, Liang, et al.
Publicado: (2016)

A single topical dose of erythropoietin applied on a collagen carrier enhances calvarial bone healing in pigs
por: Rölfing, Jan Hendrik Duedal, et al.
Publicado: (2014)

Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity
por: Kang, Ran, et al.
Publicado: (2015)

MicroRNA-155 inhibits the osteogenic differentiation of mesenchymal stem cells induced by BMP9 via downregulation of BMP signaling pathway
por: Liu, Hongxia, et al.
Publicado: (2018)

Collagen Type IV and Laminin Expressions during Cartilage Repair and in Late Clinically Failed Repair Tissues from Human Subjects
por: Foldager, Casper Bindzus, et al.
Publicado: (2016)

Deletion of RBPJK in Mesenchymal Stem Cells Enhances Osteogenic Activity by Up-Regulation of BMP Signaling
por: Shang, Xifu, et al.
Publicado: (2015)

A pilot study: Nano‐hydroxyapatite‐PEG/PLA containing low dose rhBMP2 stimulates proliferation and osteogenic differentiation of human bone marrow derived mesenchymal stem cells
por: Dede, Eda Çiftci, et al.
Publicado: (2023)

Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities
por: Berasi, Stephen P, et al.
Publicado: (2011)

Gradient Fractionated Separation of Chondrogenically Committed Cells Derived from Human Embryonic Stem Cells
por: Joergensen, Natasja Leth, et al.
Publicado: (2015)

Long non-coding RNA (LncRNA) HOTAIR regulates BMP9-induced osteogenic differentiation by targeting the proliferation of mesenchymal stem cells (MSCs)
por: Li, Ruidong, et al.
Publicado: (2021)

BMP9 exhibits dual and coupled roles in inducing osteogenic and angiogenic differentiation of mesenchymal stem cells
por: Xiao, Haozhuo, et al.
Publicado: (2020)

Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels
por: Vasilyev, Andrey Vyacheslavovich, et al.
Publicado: (2021)

Preconditioning influences mesenchymal stem cell properties in vitro and in vivo
por: Hu, Chenxia, et al.
Publicado: (2018)

Optimizing Osteogenic Differentiation of Ovine Adipose-Derived Stem Cells by Osteogenic Induction Medium and FGFb, BMP2, or NELL1 In Vitro
por: Nielsen, Emil Østergaard, et al.
Publicado: (2018)

BMP-9 Improves the Osteogenic Differentiation Ability over BMP-2 through p53 Signaling In Vitro in Human Periosteum-Derived Cells
por: Park, Jin-Ho, et al.
Publicado: (2023)

Experimental articular cartilage repair in the Göttingen minipig: the influence of multiple defects per knee
por: Christensen, Bjørn Borsøe, et al.
Publicado: (2015)

Osteogenic Differentiation of adipose mesenchymal stem cells with BMP-2 embedded microspheres in a rotating bed bioreactor
por: Boehm, Stefanie, et al.
Publicado: (2011)

Nanomaterials enhance osteogenic differentiation of human mesenchymal stem cells similar to a short peptide of BMP-7
por: Lock, Jaclyn, et al.
Publicado: (2011)

Cross-talk between EGF and BMP9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells
por: Liu, Xing, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_463lmdkjrr55obga7ge6jld1d6