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Coordinated reset stimulation in a large-scale model of the STN-GPe circuit

Synchronization of populations of neurons is a hallmark of several brain diseases. Coordinated reset (CR) stimulation is a model-based stimulation technique which specifically counteracts abnormal synchrony by desynchronization. Electrical CR stimulation, e.g., for the treatment of Parkinson's...

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Detalles Bibliográficos
Autores principales: Ebert, Martin, Hauptmann, Christian, Tass, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245901/
https://www.ncbi.nlm.nih.gov/pubmed/25505882
http://dx.doi.org/10.3389/fncom.2014.00154
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author Ebert, Martin
Hauptmann, Christian
Tass, Peter A.
author_facet Ebert, Martin
Hauptmann, Christian
Tass, Peter A.
author_sort Ebert, Martin
collection PubMed
description Synchronization of populations of neurons is a hallmark of several brain diseases. Coordinated reset (CR) stimulation is a model-based stimulation technique which specifically counteracts abnormal synchrony by desynchronization. Electrical CR stimulation, e.g., for the treatment of Parkinson's disease (PD), is administered via depth electrodes. In order to get a deeper understanding of this technique, we extended the top-down approach of previous studies and constructed a large-scale computational model of the respective brain areas. Furthermore, we took into account the spatial anatomical properties of the simulated brain structures and incorporated a detailed numerical representation of 2 · 10(4) simulated neurons. We simulated the subthalamic nucleus (STN) and the globus pallidus externus (GPe). Connections within the STN were governed by spike-timing dependent plasticity (STDP). In this way, we modeled the physiological and pathological activity of the considered brain structures. In particular, we investigated how plasticity could be exploited and how the model could be shifted from strongly synchronized (pathological) activity to strongly desynchronized (healthy) activity of the neuronal populations via CR stimulation of the STN neurons. Furthermore, we investigated the impact of specific stimulation parameters especially the electrode position on the stimulation outcome. Our model provides a step forward toward a biophysically realistic model of the brain areas relevant to the emergence of pathological neuronal activity in PD. Furthermore, our model constitutes a test bench for the optimization of both stimulation parameters and novel electrode geometries for efficient CR stimulation.
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spelling pubmed-42459012014-12-11 Coordinated reset stimulation in a large-scale model of the STN-GPe circuit Ebert, Martin Hauptmann, Christian Tass, Peter A. Front Comput Neurosci Neuroscience Synchronization of populations of neurons is a hallmark of several brain diseases. Coordinated reset (CR) stimulation is a model-based stimulation technique which specifically counteracts abnormal synchrony by desynchronization. Electrical CR stimulation, e.g., for the treatment of Parkinson's disease (PD), is administered via depth electrodes. In order to get a deeper understanding of this technique, we extended the top-down approach of previous studies and constructed a large-scale computational model of the respective brain areas. Furthermore, we took into account the spatial anatomical properties of the simulated brain structures and incorporated a detailed numerical representation of 2 · 10(4) simulated neurons. We simulated the subthalamic nucleus (STN) and the globus pallidus externus (GPe). Connections within the STN were governed by spike-timing dependent plasticity (STDP). In this way, we modeled the physiological and pathological activity of the considered brain structures. In particular, we investigated how plasticity could be exploited and how the model could be shifted from strongly synchronized (pathological) activity to strongly desynchronized (healthy) activity of the neuronal populations via CR stimulation of the STN neurons. Furthermore, we investigated the impact of specific stimulation parameters especially the electrode position on the stimulation outcome. Our model provides a step forward toward a biophysically realistic model of the brain areas relevant to the emergence of pathological neuronal activity in PD. Furthermore, our model constitutes a test bench for the optimization of both stimulation parameters and novel electrode geometries for efficient CR stimulation. Frontiers Media S.A. 2014-11-27 /pmc/articles/PMC4245901/ /pubmed/25505882 http://dx.doi.org/10.3389/fncom.2014.00154 Text en Copyright © 2014 Ebert, Hauptmann and Tass. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ebert, Martin
Hauptmann, Christian
Tass, Peter A.
Coordinated reset stimulation in a large-scale model of the STN-GPe circuit
title Coordinated reset stimulation in a large-scale model of the STN-GPe circuit
title_full Coordinated reset stimulation in a large-scale model of the STN-GPe circuit
title_fullStr Coordinated reset stimulation in a large-scale model of the STN-GPe circuit
title_full_unstemmed Coordinated reset stimulation in a large-scale model of the STN-GPe circuit
title_short Coordinated reset stimulation in a large-scale model of the STN-GPe circuit
title_sort coordinated reset stimulation in a large-scale model of the stn-gpe circuit
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245901/
https://www.ncbi.nlm.nih.gov/pubmed/25505882
http://dx.doi.org/10.3389/fncom.2014.00154
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