Biomolecular corona on nanoparticles: a survey of recent literature and its implications in targeted drug delivery

Achieving controlled cellular responses of nanoparticles (NP) is critical for the successful development and translation of NP-based drug delivery systems. However, precise control over the physicochemical and biological properties of NPs could become convoluted, diminished, or completely lost as a...

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Autores principales: Pearson, Ryan M., Juettner, Vanessa V., Hong, Seungpyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245918/
https://www.ncbi.nlm.nih.gov/pubmed/25506050
http://dx.doi.org/10.3389/fchem.2014.00108
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author Pearson, Ryan M.
Juettner, Vanessa V.
Hong, Seungpyo
author_facet Pearson, Ryan M.
Juettner, Vanessa V.
Hong, Seungpyo
author_sort Pearson, Ryan M.
collection PubMed
description Achieving controlled cellular responses of nanoparticles (NP) is critical for the successful development and translation of NP-based drug delivery systems. However, precise control over the physicochemical and biological properties of NPs could become convoluted, diminished, or completely lost as a result of the adsorption of biomolecules to their surfaces. Characterization of the formation of the “biomolecular” corona has thus received increased attention due to its impact on NP and protein structure as well as its negative effect on NP-based targeted drug delivery. This review presents a concise survey of the recent literature concerning the importance of the NP-biomolecule corona and how it can be utilized to improve the in vivo efficacy of targeted delivery systems.
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spelling pubmed-42459182014-12-11 Biomolecular corona on nanoparticles: a survey of recent literature and its implications in targeted drug delivery Pearson, Ryan M. Juettner, Vanessa V. Hong, Seungpyo Front Chem Chemistry Achieving controlled cellular responses of nanoparticles (NP) is critical for the successful development and translation of NP-based drug delivery systems. However, precise control over the physicochemical and biological properties of NPs could become convoluted, diminished, or completely lost as a result of the adsorption of biomolecules to their surfaces. Characterization of the formation of the “biomolecular” corona has thus received increased attention due to its impact on NP and protein structure as well as its negative effect on NP-based targeted drug delivery. This review presents a concise survey of the recent literature concerning the importance of the NP-biomolecule corona and how it can be utilized to improve the in vivo efficacy of targeted delivery systems. Frontiers Media S.A. 2014-11-27 /pmc/articles/PMC4245918/ /pubmed/25506050 http://dx.doi.org/10.3389/fchem.2014.00108 Text en Copyright © 2014 Pearson, Juettner and Hong. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Pearson, Ryan M.
Juettner, Vanessa V.
Hong, Seungpyo
Biomolecular corona on nanoparticles: a survey of recent literature and its implications in targeted drug delivery
title Biomolecular corona on nanoparticles: a survey of recent literature and its implications in targeted drug delivery
title_full Biomolecular corona on nanoparticles: a survey of recent literature and its implications in targeted drug delivery
title_fullStr Biomolecular corona on nanoparticles: a survey of recent literature and its implications in targeted drug delivery
title_full_unstemmed Biomolecular corona on nanoparticles: a survey of recent literature and its implications in targeted drug delivery
title_short Biomolecular corona on nanoparticles: a survey of recent literature and its implications in targeted drug delivery
title_sort biomolecular corona on nanoparticles: a survey of recent literature and its implications in targeted drug delivery
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245918/
https://www.ncbi.nlm.nih.gov/pubmed/25506050
http://dx.doi.org/10.3389/fchem.2014.00108
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