RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation

The JmjC-containing lysine demethylase, KDM4D, demethylates di-and tri-methylation of histone H3 on lysine 9 (H3K9me3). How KDM4D is recruited to chromatin and recognizes its histone substrates remains unknown. Here, we show that KDM4D binds RNA independently of its demethylase activity. We mapped t...

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Detalles Bibliográficos
Autores principales: Zoabi, Muhammad, Nadar-Ponniah, Prathamesh T., Khoury-Haddad, Hanan, Usaj, Marko, Budowski-Tal, Inbal, Haran, Tali, Henn, Arnon, Mandel-Gutfreund, Yael, Ayoub, Nabieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245933/
https://www.ncbi.nlm.nih.gov/pubmed/25378304
http://dx.doi.org/10.1093/nar/gku1021

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