Polymerase η suppresses telomere defects induced by DNA damaging agents

Telomeres at chromosome ends are normally masked from proteins that signal and repair DNA double strand breaks (DSBs). Bulky DNA lesions can cause DSBs if they block DNA replication, unless they are bypassed by translesion (TLS) DNA polymerases. Here, we investigated roles for TLS polymerase η, (pol...

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Detalles Bibliográficos
Autores principales: Pope-Varsalona, Hannah, Liu, Fu-Jun, Guzik, Lynda, Opresko, Patricia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245935/
https://www.ncbi.nlm.nih.gov/pubmed/25355508
http://dx.doi.org/10.1093/nar/gku1030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245935/
https://www.ncbi.nlm.nih.gov/pubmed/25355508
http://dx.doi.org/10.1093/nar/gku1030

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