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Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis

Human DBC1 (Deleted in Breast Cancer 1; KIAA1967; CCAR2) is a protein implicated in the regulation of apoptosis, transcription and histone modifications. Upon DNA damage, DBC1 is phosphorylated by ATM/ATR on Thr454 and this modification increases its inhibitory interaction with SIRT1, leading to p53...

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Detalles Bibliográficos
Autores principales:	Magni, Martina, Ruscica, Vincenzo, Buscemi, Giacomo, Kim, Ja-Eun, Nachimuthu, Benjamin Tamilselvan, Fontanella, Enrico, Delia, Domenico, Zannini, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245943/ https://www.ncbi.nlm.nih.gov/pubmed/25361978 http://dx.doi.org/10.1093/nar/gku1065

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