A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins

[Image: see text] Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a sol...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Won Il, Kamaly, Nazila, Riol-Blanco, Lorena, Lee, In-Hyun, Wu, Jun, Swami, Archana, Vilos, Cristian, Yameen, Basit, Yu, Mikyung, Shi, Jinjun, Tabas, Ira, von Andrian, Ulrich H., Jon, Sangyong, Farokhzad, Omid C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245989/
https://www.ncbi.nlm.nih.gov/pubmed/25333768
http://dx.doi.org/10.1021/nl502994y
Descripción
Sumario:[Image: see text] Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.

Ejemplares similares