A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins

[Image: see text] Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a sol...

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Autores principales: Choi, Won Il, Kamaly, Nazila, Riol-Blanco, Lorena, Lee, In-Hyun, Wu, Jun, Swami, Archana, Vilos, Cristian, Yameen, Basit, Yu, Mikyung, Shi, Jinjun, Tabas, Ira, von Andrian, Ulrich H., Jon, Sangyong, Farokhzad, Omid C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245989/
https://www.ncbi.nlm.nih.gov/pubmed/25333768
http://dx.doi.org/10.1021/nl502994y
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author Choi, Won Il
Kamaly, Nazila
Riol-Blanco, Lorena
Lee, In-Hyun
Wu, Jun
Swami, Archana
Vilos, Cristian
Yameen, Basit
Yu, Mikyung
Shi, Jinjun
Tabas, Ira
von Andrian, Ulrich H.
Jon, Sangyong
Farokhzad, Omid C.
author_facet Choi, Won Il
Kamaly, Nazila
Riol-Blanco, Lorena
Lee, In-Hyun
Wu, Jun
Swami, Archana
Vilos, Cristian
Yameen, Basit
Yu, Mikyung
Shi, Jinjun
Tabas, Ira
von Andrian, Ulrich H.
Jon, Sangyong
Farokhzad, Omid C.
author_sort Choi, Won Il
collection PubMed
description [Image: see text] Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.
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spelling pubmed-42459892015-10-21 A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins Choi, Won Il Kamaly, Nazila Riol-Blanco, Lorena Lee, In-Hyun Wu, Jun Swami, Archana Vilos, Cristian Yameen, Basit Yu, Mikyung Shi, Jinjun Tabas, Ira von Andrian, Ulrich H. Jon, Sangyong Farokhzad, Omid C. Nano Lett [Image: see text] Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo. American Chemical Society 2014-10-21 2014-11-12 /pmc/articles/PMC4245989/ /pubmed/25333768 http://dx.doi.org/10.1021/nl502994y Text en Copyright © 2014 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Choi, Won Il
Kamaly, Nazila
Riol-Blanco, Lorena
Lee, In-Hyun
Wu, Jun
Swami, Archana
Vilos, Cristian
Yameen, Basit
Yu, Mikyung
Shi, Jinjun
Tabas, Ira
von Andrian, Ulrich H.
Jon, Sangyong
Farokhzad, Omid C.
A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins
title A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins
title_full A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins
title_fullStr A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins
title_full_unstemmed A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins
title_short A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins
title_sort solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245989/
https://www.ncbi.nlm.nih.gov/pubmed/25333768
http://dx.doi.org/10.1021/nl502994y
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