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Classification and Management of Seeds in Retinoblastoma Ellsworth Lecture Ghent August 24th 2013
Retinoblastoma has the unique capacity to accelerate its own intra-ocular propagation by adopting semi-solid or even liquid growth properties through seeding. Until recently, the presence of any degree of seeding was mostly incompatible with successful conservative management, due to the multiresist...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Informa Healthcare USA, Inc.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245997/ https://www.ncbi.nlm.nih.gov/pubmed/25321846 http://dx.doi.org/10.3109/13816810.2014.973045 |
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author | Munier, Francis L. |
author_facet | Munier, Francis L. |
author_sort | Munier, Francis L. |
collection | PubMed |
description | Retinoblastoma has the unique capacity to accelerate its own intra-ocular propagation by adopting semi-solid or even liquid growth properties through seeding. Until recently, the presence of any degree of seeding was mostly incompatible with successful conservative management, due to the multiresistant nature of the seeds. Surprisingly, this well-recognized retinoblastoma behavior has not undergone any detailed description of seeding patterns and anatomic sites. In this paper, we describe the phenotypic variability of seeds across the four possible intraocular seeding compartments and classify them into three fundamental types: namely dust, spheres, and clouds. We also provide an overview of the different therapeutic strategies developed for seeding, with special attention to intravitreal chemotherapy as the treatment of choice for vitreous and retro-hyaloid seeding. Finally, we propose criteria to enable assessment of the response to treatment by reporting seed regression patterns, as well as a clinical grading system for the retinal toxicity observed following intravitreal melphalan. |
format | Online Article Text |
id | pubmed-4245997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Informa Healthcare USA, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-42459972014-12-08 Classification and Management of Seeds in Retinoblastoma Ellsworth Lecture Ghent August 24th 2013 Munier, Francis L. Ophthalmic Genet Research Reports Retinoblastoma has the unique capacity to accelerate its own intra-ocular propagation by adopting semi-solid or even liquid growth properties through seeding. Until recently, the presence of any degree of seeding was mostly incompatible with successful conservative management, due to the multiresistant nature of the seeds. Surprisingly, this well-recognized retinoblastoma behavior has not undergone any detailed description of seeding patterns and anatomic sites. In this paper, we describe the phenotypic variability of seeds across the four possible intraocular seeding compartments and classify them into three fundamental types: namely dust, spheres, and clouds. We also provide an overview of the different therapeutic strategies developed for seeding, with special attention to intravitreal chemotherapy as the treatment of choice for vitreous and retro-hyaloid seeding. Finally, we propose criteria to enable assessment of the response to treatment by reporting seed regression patterns, as well as a clinical grading system for the retinal toxicity observed following intravitreal melphalan. Informa Healthcare USA, Inc. 2014-12 2014-10-17 /pmc/articles/PMC4245997/ /pubmed/25321846 http://dx.doi.org/10.3109/13816810.2014.973045 Text en © Informa Healthcare USA, Inc http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the CC-BY-NC-ND 3.0 License which permits users to download and share the article for non-commercial purposes, so long as the article is reproduced in the whole without changes, and provided the original source is credited. |
spellingShingle | Research Reports Munier, Francis L. Classification and Management of Seeds in Retinoblastoma Ellsworth Lecture Ghent August 24th 2013 |
title | Classification and Management of Seeds in Retinoblastoma Ellsworth Lecture Ghent August 24th 2013 |
title_full | Classification and Management of Seeds in Retinoblastoma Ellsworth Lecture Ghent August 24th 2013 |
title_fullStr | Classification and Management of Seeds in Retinoblastoma Ellsworth Lecture Ghent August 24th 2013 |
title_full_unstemmed | Classification and Management of Seeds in Retinoblastoma Ellsworth Lecture Ghent August 24th 2013 |
title_short | Classification and Management of Seeds in Retinoblastoma Ellsworth Lecture Ghent August 24th 2013 |
title_sort | classification and management of seeds in retinoblastoma ellsworth lecture ghent august 24th 2013 |
topic | Research Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245997/ https://www.ncbi.nlm.nih.gov/pubmed/25321846 http://dx.doi.org/10.3109/13816810.2014.973045 |
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