Cargando…

Radio-sensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector

A tumor-selective non-lytic retroviral replicating vector (RRV), Toca 511, and an extended-release formulation of 5-fluorocytosine (5-FC), Toca FC, are currently being evaluated in clinical trials in patients with recurrent high-grade glioma (NCT01156584, NCT01470794, NCT01985256). Tumor-selective p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takahashi, Masamichi, Valdes, Gilmer, Hiraoka, Kei, Inagaki, Akihito, Kamijima, Shuichi, Micewicz, Ewa, Gruber, Harry E., Robbins, Joan M., Jolly, Douglas J., McBride, William H., Iwamoto, Keisuke S., Kasahara, Noriyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246057/ https://www.ncbi.nlm.nih.gov/pubmed/25301172 http://dx.doi.org/10.1038/cgt.2014.38

Ejemplares similares

Retroviral replicating vector–mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity
por: Hiraoka, Kei, et al.
Publicado: (2017)

Retroviral Replicating Vector Toca 511 (Vocimagene Amiretrorepvec) for Prodrug Activator Gene Therapy of Lung Cancer
por: Kushiya, Hiroki, et al.
Publicado: (2022)

Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model
por: Mitchell, Leah A., et al.
Publicado: (2017)

THER-06. THERAPEUTIC EFFICACY OF RRV-MEDIATED PRODRUG ACTIVATOR GENE THERAPY IN CLINICAL TRIALS OF RECURRENT HIGH-GRADE GLIOMA AND IN MURINE ORTHOTOPIC MODELS OF INTRACEREBRAL GLIOMA AND INTRACEREBELLAR MEDULLOBLASTOMA
por: Richardson, Angela, et al.
Publicado: (2020)

Dual-vector prodrug activator gene therapy using retroviral replicating vectors
por: Kubo, Shuji, et al.
Publicado: (2018)

Retroviral Replicating Vectors Mediated Prodrug Activator Gene Therapy in a Gastric Cancer Model
por: Fujino, Hiroaki, et al.
Publicado: (2023)

Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector
por: Ostertag, Derek, et al.
Publicado: (2012)

Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors (RRV) in a rodent brain tumor model
por: Yin, Dali, et al.
Publicado: (2013)

A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models
por: Yagiz, Kader, et al.
Publicado: (2017)

Maintaining therapeutic activity in the operating room: compatibility of a gamma-retroviral replicating vector with clinical materials and biofluids
por: Burnett, Ryan, et al.
Publicado: (2014)

Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model
por: Chen, Shih-Han, et al.
Publicado: (2020)

Prodrugs for Amines
por: Simplício, Ana L., et al.
Publicado: (2008)

Efficient tumor transduction and antitumor efficacy in experimental human osteosarcoma using retroviral replicating vectors
por: Kubo, Shuji, et al.
Publicado: (2018)

NRF2 Mediates Cellular Resistance to Transformation, Radiation, and Inflammation in Mice
por: Schaue, Dörthe, et al.
Publicado: (2022)

An Oral Fluorouracil Prodrug, Capecitabine, Mitigates a Gram-Positive Systemic Infection in Mice
por: McLeod, Jack R., et al.
Publicado: (2021)

A Novel Class of Antitumor Prodrug, 1‐(2′‐Oxopropyl)‐5‐fluorouracil (OFU001), That Releases 5‐Fluorouracil upon Hypoxic Irradiation
por: Shibamoto, Yuta, et al.
Publicado: (2000)

GR-891: a novel 5-fluorouracil acyclonucleoside prodrug for differentiation therapy in rhabdomyosarcoma cells
por: Marchal, J A, et al.
Publicado: (1999)

Part Two: Evaluation of N-methylbupropion as a Potential Bupropion Prodrug
por: O’Byrne, Paul Matthew, et al.
Publicado: (2014)

Radiation- and Photo-induced Activation of 5-Fluorouracil Prodrugs as a Strategy for the Selective Treatment of Solid Tumors
por: Ito, Takeo, et al.
Publicado: (2008)

A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates
por: Sun, Yixin, et al.
Publicado: (2019)

Mutual Prodrugs of 5‐Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs
por: Ciaffaglione, Valeria, et al.
Publicado: (2021)

Synthesis, Screening and Pharmacokinetic Evaluation of Potential Prodrugs of Bupropion. Part One: In Vitro Development
por: O’Byrne, Paul Matthew, et al.
Publicado: (2014)

Replication-competent retrovirus vector-mediated prodrug activator gene therapy in experimental models of human malignant mesothelioma
por: Kawasaki, Yoshiko, et al.
Publicado: (2011)

Mechanism of cell death induced by the novel enzyme-prodrug combination, nitroreductase/CB1954, and identification of synergism with 5-fluorouracil
por: Palmer, D H, et al.
Publicado: (2003)

Approaches to enhancing the retroviral transduction of human synoviocytes
por: Del Vecchio, Maria A, et al.
Publicado: (2001)

Mouse Mammary Tumor Virus Promoter-Containing Retroviral Promoter Conversion Vectors for Gene-Directed Enzyme Prodrug Therapy are Functional In Vitro and In Vivo
por: Klein, Reinhard, et al.
Publicado: (2008)

Differential Targeting of Stem Cells and Differentiated Glioblastomas by NK Cells
por: Tseng, Han-Ching, et al.
Publicado: (2015)

Eruptive keratoacanthomas secondary to topical 5-fluorouracil application
por: Cruzval-O'Reilly, Estefanía, et al.
Publicado: (2021)

Tetrazine-mediated bioorthogonal prodrug–prodrug activation
por: Neumann, Kevin, et al.
Publicado: (2018)

Prodrugs and prodrug-activated systems in gene therapy
por: Sheikh, Semira, et al.
Publicado: (2021)

A Polymeric Prodrug of 5-Fluorouracil-1-Acetic Acid Using a Multi-Hydroxyl Polyethylene Glycol Derivative as the Drug Carrier
por: Li, Man, et al.
Publicado: (2014)

Retroviral proteases
por: Dunn, Ben M, et al.
Publicado: (2002)

Retroviral Replicating Vector Delivery of miR-PDL1 Inhibits Immune Checkpoint PDL1 and Enhances Immune Responses In Vitro
por: Lin, Amy H., et al.
Publicado: (2017)

Different responses to two types of 5-fluorouracil prodrugs in combination with interferon-alpha in pulmonary metastases of renal cell carcinoma: a case report
por: Morita, Tatsuo, et al.
Publicado: (2009)

Engineering of lipid prodrug-based, hyaluronic acid-decorated nanostructured lipid carriers platform for 5-fluorouracil and cisplatin combination gastric cancer therapy
por: Qu, Chun-Ying, et al.
Publicado: (2015)

Novel mutual prodrug of 5-fluorouracil and heme oxygenase-1 inhibitor (5-FU/HO-1 hybrid): design and preliminary in vitro evaluation
por: Salerno, Loredana, et al.
Publicado: (2021)

Incidence of fistula occurrence in patients with cervical cancer treated with bevacizumab: data from real-world clinical practice
por: Sugiyama, Toru, et al.
Publicado: (2022)

Antiparkinson Prodrugs
por: Di Stefano, Antonio, et al.
Publicado: (2008)

Dendrimer Prodrugs
por: da Silva Santos, Soraya, et al.
Publicado: (2016)

Newly Developed Prodrugs and Prodrugs in Development; an Insight of the Recent Years
por: Najjar, Anas, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6qf2fgkq3dckpjj7ecnvlucs6c