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A Coiled-coil Clamp Controls Both Conformation and Clustering of Stromal Interaction Molecule 1 (STIM1)

Store-operated Ca(2+) entry, essential for the adaptive immunity, is initiated by the endoplasmic reticulum (ER) Ca(2+) sensor STIM1. Ca(2+) entry occurs through the plasma membrane resident Ca(2+) channel Orai1 that directly interacts with the C-terminal STIM1 domain, named SOAR/CAD. Depletion of t...

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Detalles Bibliográficos
Autores principales:	Fahrner, Marc, Muik, Martin, Schindl, Rainer, Butorac, Carmen, Stathopulos, Peter, Zheng, Le, Jardin, Isaac, Ikura, Mitsuhiko, Romanin, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246082/ https://www.ncbi.nlm.nih.gov/pubmed/25342749 http://dx.doi.org/10.1074/jbc.M114.610022

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