Molecular interactions of FGF23 and PTH in phosphate regulation

Bone-derived fibroblast growth factor-23 (FGF23) plays an important role in systemic phosphate turnover. Increased FGF23 activity results in hypophosphatemic, while reduced activity is linked to hyperphosphatemic disorders. FGF23, together with klotho as co-factor, can activate FGF-receptors in its...

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Autores principales: Lanske, Beate, Razzaque, Mohammed S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246422/
https://www.ncbi.nlm.nih.gov/pubmed/25427080
http://dx.doi.org/10.1038/ki.2014.316
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author Lanske, Beate
Razzaque, Mohammed S.
author_facet Lanske, Beate
Razzaque, Mohammed S.
author_sort Lanske, Beate
collection PubMed
description Bone-derived fibroblast growth factor-23 (FGF23) plays an important role in systemic phosphate turnover. Increased FGF23 activity results in hypophosphatemic, while reduced activity is linked to hyperphosphatemic disorders. FGF23, together with klotho as co-factor, can activate FGF-receptors in its target tissues to exert its functions. However, molecular regulation of FGF23 synthesis is not clearly defined, and recent studies have found that PTH can activate the nuclear receptor-associated protein-1 (Nurr1) to induce FGF23 transcription in bone cells.
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spelling pubmed-42464222015-06-01 Molecular interactions of FGF23 and PTH in phosphate regulation Lanske, Beate Razzaque, Mohammed S. Kidney Int Article Bone-derived fibroblast growth factor-23 (FGF23) plays an important role in systemic phosphate turnover. Increased FGF23 activity results in hypophosphatemic, while reduced activity is linked to hyperphosphatemic disorders. FGF23, together with klotho as co-factor, can activate FGF-receptors in its target tissues to exert its functions. However, molecular regulation of FGF23 synthesis is not clearly defined, and recent studies have found that PTH can activate the nuclear receptor-associated protein-1 (Nurr1) to induce FGF23 transcription in bone cells. 2014-12 /pmc/articles/PMC4246422/ /pubmed/25427080 http://dx.doi.org/10.1038/ki.2014.316 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Lanske, Beate
Razzaque, Mohammed S.
Molecular interactions of FGF23 and PTH in phosphate regulation
title Molecular interactions of FGF23 and PTH in phosphate regulation
title_full Molecular interactions of FGF23 and PTH in phosphate regulation
title_fullStr Molecular interactions of FGF23 and PTH in phosphate regulation
title_full_unstemmed Molecular interactions of FGF23 and PTH in phosphate regulation
title_short Molecular interactions of FGF23 and PTH in phosphate regulation
title_sort molecular interactions of fgf23 and pth in phosphate regulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246422/
https://www.ncbi.nlm.nih.gov/pubmed/25427080
http://dx.doi.org/10.1038/ki.2014.316
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