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Intralesional curettage and cementation for low-grade chondrosarcoma of long bones: retrospective study and literature review

BACKGROUND: Various treatment strategies for low-grade chondrosarcomas with variable outcomes have been reported in the literature. The aim of this study was to assess the oncological and functional outcomes associated with intralesional curettage followed by adjuvant therapy comprising high-speed b...

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Autores principales: Mermerkaya, Musa Ugur, Bekmez, Senol, Karaaslan, Fatih, Danisman, Murat, Kosemehmetoglu, Kemal, Gedikoglu, Gokhan, Ayvaz, Mehmet, Tokgozoglu, Ahmet Mazhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246483/
https://www.ncbi.nlm.nih.gov/pubmed/25382793
http://dx.doi.org/10.1186/1477-7819-12-336
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author Mermerkaya, Musa Ugur
Bekmez, Senol
Karaaslan, Fatih
Danisman, Murat
Kosemehmetoglu, Kemal
Gedikoglu, Gokhan
Ayvaz, Mehmet
Tokgozoglu, Ahmet Mazhar
author_facet Mermerkaya, Musa Ugur
Bekmez, Senol
Karaaslan, Fatih
Danisman, Murat
Kosemehmetoglu, Kemal
Gedikoglu, Gokhan
Ayvaz, Mehmet
Tokgozoglu, Ahmet Mazhar
author_sort Mermerkaya, Musa Ugur
collection PubMed
description BACKGROUND: Various treatment strategies for low-grade chondrosarcomas with variable outcomes have been reported in the literature. The aim of this study was to assess the oncological and functional outcomes associated with intralesional curettage followed by adjuvant therapy comprising high-speed burring, thermal cauterization, and bone cementation with polymethylmethacrylate. METHODS: We performed a retrospective review of 21 consecutive patients with intramedullary low-grade chondrosarcoma of long bones treated by intralesional curettage and adjuvant therapy comprising high-speed burring, thermal cauterization, and cementation at our institution from 2007 to 2012. RESULTS: The average age of the patients was 48.7 (range, 18–71) years. There were 7 male and 14 female patients. The mean follow-up period was 58.4 (range, 26–85) months after surgery. The treated lesions were located in the proximal humerus (n =10), proximal tibia (n =6), and distal femur (n =5). At the average follow-up time point of 58.4 (range, 26–85) months, no patient had developed local recurrence and no distant metastases were observed. The average Musculoskeletal Tumor Society score among all 21 patients was 95% (84–100). CONCLUSIONS: The combination of intralesional curettage, application of high-speed burring, thermal cauterization, and cementation is an effective treatment strategy for low-grade intramedullary chondrosarcoma of long bones. Excellent oncological and functional results can be obtained.
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spelling pubmed-42464832014-11-29 Intralesional curettage and cementation for low-grade chondrosarcoma of long bones: retrospective study and literature review Mermerkaya, Musa Ugur Bekmez, Senol Karaaslan, Fatih Danisman, Murat Kosemehmetoglu, Kemal Gedikoglu, Gokhan Ayvaz, Mehmet Tokgozoglu, Ahmet Mazhar World J Surg Oncol Research BACKGROUND: Various treatment strategies for low-grade chondrosarcomas with variable outcomes have been reported in the literature. The aim of this study was to assess the oncological and functional outcomes associated with intralesional curettage followed by adjuvant therapy comprising high-speed burring, thermal cauterization, and bone cementation with polymethylmethacrylate. METHODS: We performed a retrospective review of 21 consecutive patients with intramedullary low-grade chondrosarcoma of long bones treated by intralesional curettage and adjuvant therapy comprising high-speed burring, thermal cauterization, and cementation at our institution from 2007 to 2012. RESULTS: The average age of the patients was 48.7 (range, 18–71) years. There were 7 male and 14 female patients. The mean follow-up period was 58.4 (range, 26–85) months after surgery. The treated lesions were located in the proximal humerus (n =10), proximal tibia (n =6), and distal femur (n =5). At the average follow-up time point of 58.4 (range, 26–85) months, no patient had developed local recurrence and no distant metastases were observed. The average Musculoskeletal Tumor Society score among all 21 patients was 95% (84–100). CONCLUSIONS: The combination of intralesional curettage, application of high-speed burring, thermal cauterization, and cementation is an effective treatment strategy for low-grade intramedullary chondrosarcoma of long bones. Excellent oncological and functional results can be obtained. BioMed Central 2014-11-10 /pmc/articles/PMC4246483/ /pubmed/25382793 http://dx.doi.org/10.1186/1477-7819-12-336 Text en © Mermerkaya et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Mermerkaya, Musa Ugur
Bekmez, Senol
Karaaslan, Fatih
Danisman, Murat
Kosemehmetoglu, Kemal
Gedikoglu, Gokhan
Ayvaz, Mehmet
Tokgozoglu, Ahmet Mazhar
Intralesional curettage and cementation for low-grade chondrosarcoma of long bones: retrospective study and literature review
title Intralesional curettage and cementation for low-grade chondrosarcoma of long bones: retrospective study and literature review
title_full Intralesional curettage and cementation for low-grade chondrosarcoma of long bones: retrospective study and literature review
title_fullStr Intralesional curettage and cementation for low-grade chondrosarcoma of long bones: retrospective study and literature review
title_full_unstemmed Intralesional curettage and cementation for low-grade chondrosarcoma of long bones: retrospective study and literature review
title_short Intralesional curettage and cementation for low-grade chondrosarcoma of long bones: retrospective study and literature review
title_sort intralesional curettage and cementation for low-grade chondrosarcoma of long bones: retrospective study and literature review
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246483/
https://www.ncbi.nlm.nih.gov/pubmed/25382793
http://dx.doi.org/10.1186/1477-7819-12-336
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