Cargando…
Role of BC040587 as a predictor of poor outcome in breast cancer
BACKGROUND: Accumulating studies have focused on the oncogenic and tumor suppressive roles of the newly identified lncRNAs. A novel lncRNA BC040587 in 3q13.31 locus which exists frequent copy number alterations was found to be associated with poor survival of osteosarcoma patients. However, its role...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246536/ https://www.ncbi.nlm.nih.gov/pubmed/25435812 http://dx.doi.org/10.1186/s12935-014-0123-7 |
_version_ | 1782346533332582400 |
---|---|
author | Chi, Yayun Huang, Sheng Yuan, Lin Liu, Mengying Huang, Naisi Zhou, Shuling Zhou, Bingqing Wu, Jiong |
author_facet | Chi, Yayun Huang, Sheng Yuan, Lin Liu, Mengying Huang, Naisi Zhou, Shuling Zhou, Bingqing Wu, Jiong |
author_sort | Chi, Yayun |
collection | PubMed |
description | BACKGROUND: Accumulating studies have focused on the oncogenic and tumor suppressive roles of the newly identified lncRNAs. A novel lncRNA BC040587 in 3q13.31 locus which exists frequent copy number alterations was found to be associated with poor survival of osteosarcoma patients. However, its role in breast cancer (BC) remains unknown. The aim of this study was to examine the expression pattern of BC040587 in BC and to evaluate its biological role and clinical significance in prediction of prognosis. METHODS: Expression of BC040587 was analyzed in 20 pairs of BC cancer tissues and adjacent noncancerous tissues (ANCT), also in 151 BC tissues, 9 BC cell lines and one normal breast cell line by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Differences between groups were tested for significance using Student’s t-test (two-tailed). Then we analyzed the potential relationship between BC040587 expression and clinic pathological features of BC patients. The correlation was analyzed by SPSS software. RESULTS: It showed that BC040587 expression was down regulated both in BC samples and in BC cell lines compared with corresponding normal control. BC040587 expression was correlated with menopausal status (p = 0.040) and tumor differentiation (p = 0.035). The Kaplan-Meier survival curves indicated that the overall survival (OS) was significantly poor in low BC040587 expression BC patients (p = 0.023). Furthermore, expression of BC040587 was significantly associated with worse prognosis and was shown to be an independent prognostic marker breast cancer (p = 0.032). Our studies indicate that BC040587 may represent a new marker of prognosis in breast cancer. CONCLUSION: Our studies indicate that BC040587 is significantly down-regulated in BC tissues and BC cell lines. BC040587 may represent a new marker of prognosis in breast cancer. |
format | Online Article Text |
id | pubmed-4246536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42465362014-11-29 Role of BC040587 as a predictor of poor outcome in breast cancer Chi, Yayun Huang, Sheng Yuan, Lin Liu, Mengying Huang, Naisi Zhou, Shuling Zhou, Bingqing Wu, Jiong Cancer Cell Int Primary Research BACKGROUND: Accumulating studies have focused on the oncogenic and tumor suppressive roles of the newly identified lncRNAs. A novel lncRNA BC040587 in 3q13.31 locus which exists frequent copy number alterations was found to be associated with poor survival of osteosarcoma patients. However, its role in breast cancer (BC) remains unknown. The aim of this study was to examine the expression pattern of BC040587 in BC and to evaluate its biological role and clinical significance in prediction of prognosis. METHODS: Expression of BC040587 was analyzed in 20 pairs of BC cancer tissues and adjacent noncancerous tissues (ANCT), also in 151 BC tissues, 9 BC cell lines and one normal breast cell line by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Differences between groups were tested for significance using Student’s t-test (two-tailed). Then we analyzed the potential relationship between BC040587 expression and clinic pathological features of BC patients. The correlation was analyzed by SPSS software. RESULTS: It showed that BC040587 expression was down regulated both in BC samples and in BC cell lines compared with corresponding normal control. BC040587 expression was correlated with menopausal status (p = 0.040) and tumor differentiation (p = 0.035). The Kaplan-Meier survival curves indicated that the overall survival (OS) was significantly poor in low BC040587 expression BC patients (p = 0.023). Furthermore, expression of BC040587 was significantly associated with worse prognosis and was shown to be an independent prognostic marker breast cancer (p = 0.032). Our studies indicate that BC040587 may represent a new marker of prognosis in breast cancer. CONCLUSION: Our studies indicate that BC040587 is significantly down-regulated in BC tissues and BC cell lines. BC040587 may represent a new marker of prognosis in breast cancer. BioMed Central 2014-11-26 /pmc/articles/PMC4246536/ /pubmed/25435812 http://dx.doi.org/10.1186/s12935-014-0123-7 Text en © Chi et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Primary Research Chi, Yayun Huang, Sheng Yuan, Lin Liu, Mengying Huang, Naisi Zhou, Shuling Zhou, Bingqing Wu, Jiong Role of BC040587 as a predictor of poor outcome in breast cancer |
title | Role of BC040587 as a predictor of poor outcome in breast cancer |
title_full | Role of BC040587 as a predictor of poor outcome in breast cancer |
title_fullStr | Role of BC040587 as a predictor of poor outcome in breast cancer |
title_full_unstemmed | Role of BC040587 as a predictor of poor outcome in breast cancer |
title_short | Role of BC040587 as a predictor of poor outcome in breast cancer |
title_sort | role of bc040587 as a predictor of poor outcome in breast cancer |
topic | Primary Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246536/ https://www.ncbi.nlm.nih.gov/pubmed/25435812 http://dx.doi.org/10.1186/s12935-014-0123-7 |
work_keys_str_mv | AT chiyayun roleofbc040587asapredictorofpooroutcomeinbreastcancer AT huangsheng roleofbc040587asapredictorofpooroutcomeinbreastcancer AT yuanlin roleofbc040587asapredictorofpooroutcomeinbreastcancer AT liumengying roleofbc040587asapredictorofpooroutcomeinbreastcancer AT huangnaisi roleofbc040587asapredictorofpooroutcomeinbreastcancer AT zhoushuling roleofbc040587asapredictorofpooroutcomeinbreastcancer AT zhoubingqing roleofbc040587asapredictorofpooroutcomeinbreastcancer AT wujiong roleofbc040587asapredictorofpooroutcomeinbreastcancer |