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Craniopharyngioma: Survivin expression and ultrastructure
The aim of the present study was to investigate the significance of survivin protein expression levels in craniopharyngioma. Tumor samples and clinical data were obtained from 50 patients with craniopharyngioma who were admitted to the West China Hospital of Sichuan University (Chengdu, China). The...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246612/ https://www.ncbi.nlm.nih.gov/pubmed/25435936 http://dx.doi.org/10.3892/ol.2014.2690 |
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author | ZHU, JIANG YOU, CHAO |
author_facet | ZHU, JIANG YOU, CHAO |
author_sort | ZHU, JIANG |
collection | PubMed |
description | The aim of the present study was to investigate the significance of survivin protein expression levels in craniopharyngioma. Tumor samples and clinical data were obtained from 50 patients with craniopharyngioma who were admitted to the West China Hospital of Sichuan University (Chengdu, China). The morphology of the craniopharyngioma samples was observed using optical and electron microscopes, and survivin expression was investigated in the samples by immunohistochemical analysis. The immunohistochemical results revealed survivin expression in all of the craniopharyngioma samples, but not in the healthy brain tissue samples. It was identified that survivin was expressed at a higher level in cases of the adamantinomatous type compared with those of the squamous-papillary type, in male patients compared with female patients, in children compared with adults and in recurrent cases compared with non-recurrent cases. Furthermore, no significant difference was detected in survivin expression levels among the tumors of different subtypes and different disease stages. The results of the present study indicate that survivin is significant in the development of craniopharyngioma, and that survivin protein expression levels are a meaningful indicator for assessing craniopharyngioma recurrence. |
format | Online Article Text |
id | pubmed-4246612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-42466122014-11-28 Craniopharyngioma: Survivin expression and ultrastructure ZHU, JIANG YOU, CHAO Oncol Lett Articles The aim of the present study was to investigate the significance of survivin protein expression levels in craniopharyngioma. Tumor samples and clinical data were obtained from 50 patients with craniopharyngioma who were admitted to the West China Hospital of Sichuan University (Chengdu, China). The morphology of the craniopharyngioma samples was observed using optical and electron microscopes, and survivin expression was investigated in the samples by immunohistochemical analysis. The immunohistochemical results revealed survivin expression in all of the craniopharyngioma samples, but not in the healthy brain tissue samples. It was identified that survivin was expressed at a higher level in cases of the adamantinomatous type compared with those of the squamous-papillary type, in male patients compared with female patients, in children compared with adults and in recurrent cases compared with non-recurrent cases. Furthermore, no significant difference was detected in survivin expression levels among the tumors of different subtypes and different disease stages. The results of the present study indicate that survivin is significant in the development of craniopharyngioma, and that survivin protein expression levels are a meaningful indicator for assessing craniopharyngioma recurrence. D.A. Spandidos 2015-01 2014-11-07 /pmc/articles/PMC4246612/ /pubmed/25435936 http://dx.doi.org/10.3892/ol.2014.2690 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles ZHU, JIANG YOU, CHAO Craniopharyngioma: Survivin expression and ultrastructure |
title | Craniopharyngioma: Survivin expression and ultrastructure |
title_full | Craniopharyngioma: Survivin expression and ultrastructure |
title_fullStr | Craniopharyngioma: Survivin expression and ultrastructure |
title_full_unstemmed | Craniopharyngioma: Survivin expression and ultrastructure |
title_short | Craniopharyngioma: Survivin expression and ultrastructure |
title_sort | craniopharyngioma: survivin expression and ultrastructure |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246612/ https://www.ncbi.nlm.nih.gov/pubmed/25435936 http://dx.doi.org/10.3892/ol.2014.2690 |
work_keys_str_mv | AT zhujiang craniopharyngiomasurvivinexpressionandultrastructure AT youchao craniopharyngiomasurvivinexpressionandultrastructure |