Ki67 as a predictor of poor prognosis in patients with triple-negative breast cancer

The aim of the current study was to investigate the expression of the proliferation antigen, Ki67, in triple-negative breast cancer (TNBC) and its correlation with clinicopathological factors. The expression of Ki67 and other biological indicators in 24 cases of TNBC tissues and 178 cases of non-TNB...

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Autores principales: LI, HAITAO, HAN, XINGHUA, LIU, YINGXIN, LIU, GUODONG, DONG, GUOMIN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246616/
https://www.ncbi.nlm.nih.gov/pubmed/25435949
http://dx.doi.org/10.3892/ol.2014.2618
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author LI, HAITAO
HAN, XINGHUA
LIU, YINGXIN
LIU, GUODONG
DONG, GUOMIN
author_facet LI, HAITAO
HAN, XINGHUA
LIU, YINGXIN
LIU, GUODONG
DONG, GUOMIN
author_sort LI, HAITAO
collection PubMed
description The aim of the current study was to investigate the expression of the proliferation antigen, Ki67, in triple-negative breast cancer (TNBC) and its correlation with clinicopathological factors. The expression of Ki67 and other biological indicators in 24 cases of TNBC tissues and 178 cases of non-TNBC tissues were detected using immunohistochemistry. Their correlation with the clinicopathological factors were also analyzed using the χ(2) test. The positive rate of Ki67 expression in TNBC tissues was 83.3%, exhibiting a statistically significant difference when compared with that in non-TNBC tissues (73.0%) (P<0.05). The expression of Ki67 in breast cancer tissue significantly correlated with the tumor size and lymph node metastases; however, no correlation was observed with the age and the clinical stage. Ki67 may be an indicator of poor prognosis in TNBC patients.
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spelling pubmed-42466162014-11-28 Ki67 as a predictor of poor prognosis in patients with triple-negative breast cancer LI, HAITAO HAN, XINGHUA LIU, YINGXIN LIU, GUODONG DONG, GUOMIN Oncol Lett Articles The aim of the current study was to investigate the expression of the proliferation antigen, Ki67, in triple-negative breast cancer (TNBC) and its correlation with clinicopathological factors. The expression of Ki67 and other biological indicators in 24 cases of TNBC tissues and 178 cases of non-TNBC tissues were detected using immunohistochemistry. Their correlation with the clinicopathological factors were also analyzed using the χ(2) test. The positive rate of Ki67 expression in TNBC tissues was 83.3%, exhibiting a statistically significant difference when compared with that in non-TNBC tissues (73.0%) (P<0.05). The expression of Ki67 in breast cancer tissue significantly correlated with the tumor size and lymph node metastases; however, no correlation was observed with the age and the clinical stage. Ki67 may be an indicator of poor prognosis in TNBC patients. D.A. Spandidos 2015-01 2014-10-15 /pmc/articles/PMC4246616/ /pubmed/25435949 http://dx.doi.org/10.3892/ol.2014.2618 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
LI, HAITAO
HAN, XINGHUA
LIU, YINGXIN
LIU, GUODONG
DONG, GUOMIN
Ki67 as a predictor of poor prognosis in patients with triple-negative breast cancer
title Ki67 as a predictor of poor prognosis in patients with triple-negative breast cancer
title_full Ki67 as a predictor of poor prognosis in patients with triple-negative breast cancer
title_fullStr Ki67 as a predictor of poor prognosis in patients with triple-negative breast cancer
title_full_unstemmed Ki67 as a predictor of poor prognosis in patients with triple-negative breast cancer
title_short Ki67 as a predictor of poor prognosis in patients with triple-negative breast cancer
title_sort ki67 as a predictor of poor prognosis in patients with triple-negative breast cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246616/
https://www.ncbi.nlm.nih.gov/pubmed/25435949
http://dx.doi.org/10.3892/ol.2014.2618
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