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Clinical Features in Patients with Long-Lasting Macrophagic Myofasciitis

Macrophagic myofasciitis (MMF) is an emerging condition characterized by specific muscle lesions assessing abnormal long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization. Affected patients usually are middle-aged adults, mainly presenting with diffuse ar...

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Autores principales: Rigolet, Muriel, Aouizerate, Jessie, Couette, Maryline, Ragunathan-Thangarajah, Nilusha, Aoun-Sebaiti, Mehdi, Gherardi, Romain Kroum, Cadusseau, Josette, Authier, François Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246686/
https://www.ncbi.nlm.nih.gov/pubmed/25506338
http://dx.doi.org/10.3389/fneur.2014.00230
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author Rigolet, Muriel
Aouizerate, Jessie
Couette, Maryline
Ragunathan-Thangarajah, Nilusha
Aoun-Sebaiti, Mehdi
Gherardi, Romain Kroum
Cadusseau, Josette
Authier, François Jérôme
author_facet Rigolet, Muriel
Aouizerate, Jessie
Couette, Maryline
Ragunathan-Thangarajah, Nilusha
Aoun-Sebaiti, Mehdi
Gherardi, Romain Kroum
Cadusseau, Josette
Authier, François Jérôme
author_sort Rigolet, Muriel
collection PubMed
description Macrophagic myofasciitis (MMF) is an emerging condition characterized by specific muscle lesions assessing abnormal long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization. Affected patients usually are middle-aged adults, mainly presenting with diffuse arthromyalgias, chronic fatigue, and marked cognitive deficits, not related to pain, fatigue, or depression. Clinical features usually correspond to that observed in chronic fatigue syndrome/myalgic encephalomyelitis. Representative features of MMF-associated cognitive dysfunction include dysexecutive syndrome, visual memory impairment, and left ear extinction at dichotic listening test. Most patients fulfill criteria for non-amnestic/dysexecutive mild cognitive impairment, even if some cognitive deficits appear unusually severe. Cognitive dysfunction seems stable over time despite marked fluctuations. Evoked potentials may show abnormalities in keeping with central nervous system involvement, with a neurophysiological pattern suggestive of demyelination. Brain perfusion SPECT shows a pattern of diffuse cortical and subcortical abnormalities, with hypoperfusions correlating with cognitive deficiencies. The combination of musculoskeletal pain, chronic fatigue, and cognitive disturbance generates chronic disability with possible social exclusion. Classical therapeutic approaches are usually unsatisfactory making patient care difficult.
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spelling pubmed-42466862014-12-12 Clinical Features in Patients with Long-Lasting Macrophagic Myofasciitis Rigolet, Muriel Aouizerate, Jessie Couette, Maryline Ragunathan-Thangarajah, Nilusha Aoun-Sebaiti, Mehdi Gherardi, Romain Kroum Cadusseau, Josette Authier, François Jérôme Front Neurol Neuroscience Macrophagic myofasciitis (MMF) is an emerging condition characterized by specific muscle lesions assessing abnormal long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization. Affected patients usually are middle-aged adults, mainly presenting with diffuse arthromyalgias, chronic fatigue, and marked cognitive deficits, not related to pain, fatigue, or depression. Clinical features usually correspond to that observed in chronic fatigue syndrome/myalgic encephalomyelitis. Representative features of MMF-associated cognitive dysfunction include dysexecutive syndrome, visual memory impairment, and left ear extinction at dichotic listening test. Most patients fulfill criteria for non-amnestic/dysexecutive mild cognitive impairment, even if some cognitive deficits appear unusually severe. Cognitive dysfunction seems stable over time despite marked fluctuations. Evoked potentials may show abnormalities in keeping with central nervous system involvement, with a neurophysiological pattern suggestive of demyelination. Brain perfusion SPECT shows a pattern of diffuse cortical and subcortical abnormalities, with hypoperfusions correlating with cognitive deficiencies. The combination of musculoskeletal pain, chronic fatigue, and cognitive disturbance generates chronic disability with possible social exclusion. Classical therapeutic approaches are usually unsatisfactory making patient care difficult. Frontiers Media S.A. 2014-11-28 /pmc/articles/PMC4246686/ /pubmed/25506338 http://dx.doi.org/10.3389/fneur.2014.00230 Text en Copyright © 2014 Rigolet, Aouizerate, Couette, Ragunathan-Thangarajah, Aoun-Sebaiti, Gherardi, Cadusseau and Authier. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Rigolet, Muriel
Aouizerate, Jessie
Couette, Maryline
Ragunathan-Thangarajah, Nilusha
Aoun-Sebaiti, Mehdi
Gherardi, Romain Kroum
Cadusseau, Josette
Authier, François Jérôme
Clinical Features in Patients with Long-Lasting Macrophagic Myofasciitis
title Clinical Features in Patients with Long-Lasting Macrophagic Myofasciitis
title_full Clinical Features in Patients with Long-Lasting Macrophagic Myofasciitis
title_fullStr Clinical Features in Patients with Long-Lasting Macrophagic Myofasciitis
title_full_unstemmed Clinical Features in Patients with Long-Lasting Macrophagic Myofasciitis
title_short Clinical Features in Patients with Long-Lasting Macrophagic Myofasciitis
title_sort clinical features in patients with long-lasting macrophagic myofasciitis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246686/
https://www.ncbi.nlm.nih.gov/pubmed/25506338
http://dx.doi.org/10.3389/fneur.2014.00230
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