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Natriuretic Hormones in Brain Function
Natriuretic hormones (NH) include three groups of compounds: the natriuretic peptides (ANP, BNP and CNP), the gastrointestinal peptides (guanylin and uroguanylin), and endogenous cardiac steroids. These substances induce the kidney to excrete sodium and therefore participate in the regulation of sod...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246887/ https://www.ncbi.nlm.nih.gov/pubmed/25506340 http://dx.doi.org/10.3389/fendo.2014.00201 |
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author | Hodes, Anastasia Lichtstein, David |
author_facet | Hodes, Anastasia Lichtstein, David |
author_sort | Hodes, Anastasia |
collection | PubMed |
description | Natriuretic hormones (NH) include three groups of compounds: the natriuretic peptides (ANP, BNP and CNP), the gastrointestinal peptides (guanylin and uroguanylin), and endogenous cardiac steroids. These substances induce the kidney to excrete sodium and therefore participate in the regulation of sodium and water homeostasis, blood volume, and blood pressure (BP). In addition to their peripheral functions, these hormones act as neurotransmitters or neuromodulators in the brain. In this review, the established information on the biosynthesis, release and function of NH is discussed, with particular focus on their role in brain function. The available literature on the expression patterns of each of the NH and their receptors in the brain is summarized, followed by the evidence for their roles in modulating brain function. Although numerous open questions exist regarding this issue, the available data support the notion that NH participate in the central regulation of BP, neuroprotection, satiety, and various psychiatric conditions, including anxiety, addiction, and depressive disorders. In addition, the interactions between the different NH in the periphery and the brain are discussed. |
format | Online Article Text |
id | pubmed-4246887 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-42468872014-12-12 Natriuretic Hormones in Brain Function Hodes, Anastasia Lichtstein, David Front Endocrinol (Lausanne) Endocrinology Natriuretic hormones (NH) include three groups of compounds: the natriuretic peptides (ANP, BNP and CNP), the gastrointestinal peptides (guanylin and uroguanylin), and endogenous cardiac steroids. These substances induce the kidney to excrete sodium and therefore participate in the regulation of sodium and water homeostasis, blood volume, and blood pressure (BP). In addition to their peripheral functions, these hormones act as neurotransmitters or neuromodulators in the brain. In this review, the established information on the biosynthesis, release and function of NH is discussed, with particular focus on their role in brain function. The available literature on the expression patterns of each of the NH and their receptors in the brain is summarized, followed by the evidence for their roles in modulating brain function. Although numerous open questions exist regarding this issue, the available data support the notion that NH participate in the central regulation of BP, neuroprotection, satiety, and various psychiatric conditions, including anxiety, addiction, and depressive disorders. In addition, the interactions between the different NH in the periphery and the brain are discussed. Frontiers Media S.A. 2014-11-28 /pmc/articles/PMC4246887/ /pubmed/25506340 http://dx.doi.org/10.3389/fendo.2014.00201 Text en Copyright © 2014 Hodes and Lichtstein. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Hodes, Anastasia Lichtstein, David Natriuretic Hormones in Brain Function |
title | Natriuretic Hormones in Brain Function |
title_full | Natriuretic Hormones in Brain Function |
title_fullStr | Natriuretic Hormones in Brain Function |
title_full_unstemmed | Natriuretic Hormones in Brain Function |
title_short | Natriuretic Hormones in Brain Function |
title_sort | natriuretic hormones in brain function |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246887/ https://www.ncbi.nlm.nih.gov/pubmed/25506340 http://dx.doi.org/10.3389/fendo.2014.00201 |
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