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Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review

Adrenocortical carcinoma (ACC) is a rare, but highly aggressive type of tumor with an incidence of one to two per million annually. Adrenocortical carcinosarcoma is an exceptional variant of ACC, which is characterized by the presence of histological regions of carcinoma and sarcoma. To date, to the...

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Autores principales: WEI, YONG-BAO, GAO, YUN-LIANG, WU, HONG-TAO, OU-YANG, SHI-FENG, XU, TAO, MAO, DONG-FANG, YANG, JIN-RUI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247116/
https://www.ncbi.nlm.nih.gov/pubmed/25435950
http://dx.doi.org/10.3892/ol.2014.2635
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author WEI, YONG-BAO
GAO, YUN-LIANG
WU, HONG-TAO
OU-YANG, SHI-FENG
XU, TAO
MAO, DONG-FANG
YANG, JIN-RUI
author_facet WEI, YONG-BAO
GAO, YUN-LIANG
WU, HONG-TAO
OU-YANG, SHI-FENG
XU, TAO
MAO, DONG-FANG
YANG, JIN-RUI
author_sort WEI, YONG-BAO
collection PubMed
description Adrenocortical carcinoma (ACC) is a rare, but highly aggressive type of tumor with an incidence of one to two per million annually. Adrenocortical carcinosarcoma is an exceptional variant of ACC, which is characterized by the presence of histological regions of carcinoma and sarcoma. To date, to the best of our knowledge, there have only been 12 reported cases of adrenocortical carcinosarcoma. In the present study, a case of primary, non-functional adrenocortical carcinosarcoma is described, as well as a review of the literature to raise awareness of this particularly rare type of malignant neoplasm that is associated with a worse diagnosis and prognosis than adrenocortical carcinoma. In the present study, the patient underwent a laparoscopic left adrenalectomy and the tumor was dissected without complication from the left kidney. Microscopic observations showed the tumor comprised of epithelial and spindle cell components. The patient did not exhibit signs of tumor recurrence at the one-month follow-up. The potential diagnosis of adrenocortical carcinosarcoma must be considered when diagnosing adrenal malignancies in adults. In addition, comphrensive imunohistochemical staining may be required to identify possible sarcomatous patterns. To the best of our knowledge, the present case is the first to report an incidence of adrenocortical carcinosarcoma in China. Details of the patient are presented and the pathology of adrenocortical carcinosarcoma is discussed.
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spelling pubmed-42471162014-11-28 Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review WEI, YONG-BAO GAO, YUN-LIANG WU, HONG-TAO OU-YANG, SHI-FENG XU, TAO MAO, DONG-FANG YANG, JIN-RUI Oncol Lett Articles Adrenocortical carcinoma (ACC) is a rare, but highly aggressive type of tumor with an incidence of one to two per million annually. Adrenocortical carcinosarcoma is an exceptional variant of ACC, which is characterized by the presence of histological regions of carcinoma and sarcoma. To date, to the best of our knowledge, there have only been 12 reported cases of adrenocortical carcinosarcoma. In the present study, a case of primary, non-functional adrenocortical carcinosarcoma is described, as well as a review of the literature to raise awareness of this particularly rare type of malignant neoplasm that is associated with a worse diagnosis and prognosis than adrenocortical carcinoma. In the present study, the patient underwent a laparoscopic left adrenalectomy and the tumor was dissected without complication from the left kidney. Microscopic observations showed the tumor comprised of epithelial and spindle cell components. The patient did not exhibit signs of tumor recurrence at the one-month follow-up. The potential diagnosis of adrenocortical carcinosarcoma must be considered when diagnosing adrenal malignancies in adults. In addition, comphrensive imunohistochemical staining may be required to identify possible sarcomatous patterns. To the best of our knowledge, the present case is the first to report an incidence of adrenocortical carcinosarcoma in China. Details of the patient are presented and the pathology of adrenocortical carcinosarcoma is discussed. D.A. Spandidos 2015-01 2014-10-24 /pmc/articles/PMC4247116/ /pubmed/25435950 http://dx.doi.org/10.3892/ol.2014.2635 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
WEI, YONG-BAO
GAO, YUN-LIANG
WU, HONG-TAO
OU-YANG, SHI-FENG
XU, TAO
MAO, DONG-FANG
YANG, JIN-RUI
Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review
title Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review
title_full Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review
title_fullStr Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review
title_full_unstemmed Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review
title_short Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review
title_sort rare incidence of primary adrenocortical carcinosarcoma: a case report and literature review
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247116/
https://www.ncbi.nlm.nih.gov/pubmed/25435950
http://dx.doi.org/10.3892/ol.2014.2635
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