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Rehabilitation for a child with recalcitrant anti-N-methyl-d-aspartate receptor encephalitis: case report and literature review

Anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis is a newly recognized, potentially fatal, but treatable autoimmune disease. Good outcome predictors include milder severity of symptoms, no need for intensive care unit admission, early aggressive immunotherapy, and prompt tumor removal. We...

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Autores principales: Guo, Yao-Hong, Kuan, Ta-Shen, Hsieh, Pei-Chun, Lien, Wei-Chih, Chang, Chun-Kai, Lin, Yu-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247148/
https://www.ncbi.nlm.nih.gov/pubmed/25473290
http://dx.doi.org/10.2147/NDT.S74205
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author Guo, Yao-Hong
Kuan, Ta-Shen
Hsieh, Pei-Chun
Lien, Wei-Chih
Chang, Chun-Kai
Lin, Yu-Ching
author_facet Guo, Yao-Hong
Kuan, Ta-Shen
Hsieh, Pei-Chun
Lien, Wei-Chih
Chang, Chun-Kai
Lin, Yu-Ching
author_sort Guo, Yao-Hong
collection PubMed
description Anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis is a newly recognized, potentially fatal, but treatable autoimmune disease. Good outcome predictors include milder severity of symptoms, no need for intensive care unit admission, early aggressive immunotherapy, and prompt tumor removal. We report a case of a young girl aged 3 years 2 months and diagnosed as recalcitrant anti-NMDA receptor encephalitis without any underlying neoplasm. The patient had initial symptoms of behavioral changes that progressed to generalized choreoathetosis and orofacial dyskinesia, which resulted in 6 months of hospitalization in the pediatric intensive care unit. One year after initial onset of the disease, she had only achieved the developmental age of an infant aged 6–8 months in terms of gross and fine motor skills, but she resumed total independence in activities of daily living after receiving extensive immunotherapy and 28 months of rehabilitation. Our brief review will help clinical practitioners become more familiar with this disease and the unique rehabilitation programs.
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spelling pubmed-42471482014-12-03 Rehabilitation for a child with recalcitrant anti-N-methyl-d-aspartate receptor encephalitis: case report and literature review Guo, Yao-Hong Kuan, Ta-Shen Hsieh, Pei-Chun Lien, Wei-Chih Chang, Chun-Kai Lin, Yu-Ching Neuropsychiatr Dis Treat Case Report Anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis is a newly recognized, potentially fatal, but treatable autoimmune disease. Good outcome predictors include milder severity of symptoms, no need for intensive care unit admission, early aggressive immunotherapy, and prompt tumor removal. We report a case of a young girl aged 3 years 2 months and diagnosed as recalcitrant anti-NMDA receptor encephalitis without any underlying neoplasm. The patient had initial symptoms of behavioral changes that progressed to generalized choreoathetosis and orofacial dyskinesia, which resulted in 6 months of hospitalization in the pediatric intensive care unit. One year after initial onset of the disease, she had only achieved the developmental age of an infant aged 6–8 months in terms of gross and fine motor skills, but she resumed total independence in activities of daily living after receiving extensive immunotherapy and 28 months of rehabilitation. Our brief review will help clinical practitioners become more familiar with this disease and the unique rehabilitation programs. Dove Medical Press 2014-11-24 /pmc/articles/PMC4247148/ /pubmed/25473290 http://dx.doi.org/10.2147/NDT.S74205 Text en © 2014 Guo et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Report
Guo, Yao-Hong
Kuan, Ta-Shen
Hsieh, Pei-Chun
Lien, Wei-Chih
Chang, Chun-Kai
Lin, Yu-Ching
Rehabilitation for a child with recalcitrant anti-N-methyl-d-aspartate receptor encephalitis: case report and literature review
title Rehabilitation for a child with recalcitrant anti-N-methyl-d-aspartate receptor encephalitis: case report and literature review
title_full Rehabilitation for a child with recalcitrant anti-N-methyl-d-aspartate receptor encephalitis: case report and literature review
title_fullStr Rehabilitation for a child with recalcitrant anti-N-methyl-d-aspartate receptor encephalitis: case report and literature review
title_full_unstemmed Rehabilitation for a child with recalcitrant anti-N-methyl-d-aspartate receptor encephalitis: case report and literature review
title_short Rehabilitation for a child with recalcitrant anti-N-methyl-d-aspartate receptor encephalitis: case report and literature review
title_sort rehabilitation for a child with recalcitrant anti-n-methyl-d-aspartate receptor encephalitis: case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247148/
https://www.ncbi.nlm.nih.gov/pubmed/25473290
http://dx.doi.org/10.2147/NDT.S74205
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