Cargando…
The impact of human and mouse differences in NOS2 gene expression on the brain’s redox and immune environment
BACKGROUND: Mouse models are used in the study of human disease. Despite well-known homologies, the difference in immune response between mice and humans impacts the application of data derived from mice to human disease outcomes. Nitric oxide synthase-2 (NOS2) is a key gene that displays species-sp...
Autores principales: | Hoos, Michael D, Vitek, Michael P, Ridnour, Lisa A, Wilson, Joan, Jansen, Marilyn, Everhart, Angela, Wink, David A, Colton, Carol A |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247207/ https://www.ncbi.nlm.nih.gov/pubmed/25403885 http://dx.doi.org/10.1186/1750-1326-9-50 |
Ejemplares similares
-
mNos2 Deletion and Human NOS2 Replacement in Alzheimer Disease Models
por: Colton, Carol A., et al.
Publicado: (2014) -
Lithium Treatment of APPSwDI/NOS2−/− Mice Leads to Reduced Hyperphosphorylated Tau, Increased Amyloid Deposition and Altered Inflammatory Phenotype
por: Sudduth, Tiffany L., et al.
Publicado: (2012) -
Metabolism-Based Gene Differences in Neurons Expressing Hyperphosphorylated AT8− Positive (AT8+) Tau in Alzheimer’s Disease
por: York, Audra, et al.
Publicado: (2021) -
Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence
por: Wilcock, Donna M, et al.
Publicado: (2011) -
Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses
por: Wilcock, Donna M, et al.
Publicado: (2011)